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master's thesis
Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. urn:nbn:hr:163:124368
Gilja, Petra
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Gilja, P. (2016). Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:124368

Gilja, Petra. "Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:124368

Gilja, Petra. "Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:124368

Gilja, P. (2016). 'Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:124368

Gilja P. Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2016 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:163:124368

P. Gilja, "Sinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:163:124368

Metadata
TitleSinteza i karakterizacija novih acilsemikarbazidnih derivata cimetne kiseline i primakina
Title (english)Synthesis and characterization of novel acylsemicarbazide cinnamic acid-primaquine derivatives
AuthorPetra Gilja
MentorIvana Perković (mentor)
Committee memberIvana Perković (predsjednik povjerenstva)
Committee memberBranka Zorc (član povjerenstva)
Committee memberMiranda Sertić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2016-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Ovaj rad se nadovezuje na višegodišnja istraživanja provedena na Zavodu za farmaceutsku kemiju Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu koja obuhvaćaju dizajniranje, sintezu i biološku evaluaciju derivata primakina s antiproliferativnim djelovanjem. Rezultati tih istraživanja, uz literaturne izvore o biološkim djelovanjima derivata cimetne kiseline, temelj su dizajna novih derivata primakina i cimetne kiseline kao potencijalnih citostatika. Cilj ovog rada bila je sinteza i karakterizacija šest novih acilsemikarbazidnih derivata primakina koji u svojoj strukturi sadrže derivate cimetne kiseline. Kao početni spoj u sintezi korišten je klorid 1-benzotriazolkarboksilne kiseline, BtcCl (1). Primakin je reakcijom s BtcCl preveden u primakinski benzotriazolid (2), a zatim pomoću hidrazina u primakinski semikarbazid (3). Derivati cimetne kiseline prevedeni su u kiselinske kloride 4a-f reakcijom s tionil-kloridom. Reakcijom primakinskog semikarbazida (3) s kloridom odgovarajućeg derivata cimetne kiseline 4a-f dobiveni su acilsemikarbazidni derivati 5a-f koji nisu do sad opisani u literaturi. Strukture svih sintetiziranih spojeva potvrđene su uobičajenim spektroskopskim metodama (IR, 1H i 13C NMR, MS). Čvrstim produktima određeno je talište. Sintetiziranim derivatima će u daljnjim istraživanjima biti ispitano biološko djelovanje.
Abstract (english)
In the last few years, a research group at the Department of Medicinal Chemistry has focused on primaquine derivatization. This includes design, synthesis and biological evaluation of novel primaquine derivatives with antiproliferative activity. The purpose of this research was synthesis and characterization of six novel primaquine derivatives that include cinnamid acid derivatives (CADs) in their structure. The reaction of 1- benzotriazolecarboxylic acid chloride (BtcCl, 1) with primaquine (PQ) gave primaquine benzotriazolide (2). Primaquine semicarbazide (3) was prepared in the reaction of primaquine benzotriazolide (2) with hydrazine. Cinnamic acid derivatives (CAD) gave acyl chlorides 4a-f in the reaction with thyonil chloride. Final products, acylsemicarbazide CAD-PQ derivatives 5a-f were finally obtained in the reaction of primaquine semicarbazide (3) and corresponding acyl chlorides 4a-f. Structures of newly prepared primaquine derivatives were confirmed by IR, 1H and 13C NMR spectroscopy and MS. Melting point of solid compounds were also determined. Antiproliferative activity of synthesized primaquine derivatives will be tested in further analysis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:124368
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-12-05 10:17:35