Cardiomyopathy refers to diseases of heart muscle and it often leads to heart failure. Trying to improve diagnosis of disease, laboratoy scientists are developing new biochemistry markers that can be reliable and precise marker of the disease. Cardiac remodeling is the final clue that is needed to be more explained. There are many different variables which take part in development or progression of the cardiomyopathy. That variables also known as biomarkers are considers as „culprit“ if they play role in development, or as a „bystander“ if they represents result. The study included 65 patients with cardiomyopathy. We determined concentrations of CA 125, NT-proBNP and galectin-3. The aim of the work was to confirm increased concentration of this there biomarkers in our grupe of patients and to assess their interdependence. Statistical analysis of variables confirmed interdependence between CA 125 and NT-proBNP, but interdependence between galectin-3 and two another variables haven't been confirmed in this study. We also confirmed elevated concentrations of these biomarkes and their corelation with NYHA functional classification, which is already established in literature, and it leads to new, bigger studies of the clincal utility as biomarkes of diagnosis, prognossis and therapy treatment. Defining NYHA stages based on determination of biochemistry markers is reliable only if we include together these three relevant variables - NT-proBNO, CA 125 and galectin-3.