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master's thesis
Pleiotropni učinci metformina
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. urn:nbn:hr:163:717625
Smolčić, Katarina
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Smolčić, K. (2016). Pleiotropni učinci metformina (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:717625

Smolčić, Katarina. "Pleiotropni učinci metformina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:717625

Smolčić, Katarina. "Pleiotropni učinci metformina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:717625

Smolčić, K. (2016). 'Pleiotropni učinci metformina', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:717625

Smolčić K. Pleiotropni učinci metformina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2016 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:163:717625

K. Smolčić, "Pleiotropni učinci metformina", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:163:717625

Metadata
TitlePleiotropni učinci metformina
Title (english)Pleiotropic effects of metformin
AuthorKatarina Smolčić
MentorPetra Turčić (mentor)
Committee memberPetra Turčić (predsjednik povjerenstva)
Committee memberAna-Marija Domijan (član povjerenstva)
Committee memberMiranda Sertić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2016-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom teorijskom diplomskom radu prikazana su farmakološka svojstva i terapijski potencijal metformina. Prema svjetskim i hrvatskim smjernicama za liječenje dijabetesa tipa 2 metformin je lijek prvog izbora. Posebna vrijednost ovog lijeka su snažni klinički dokazi o pozitivnim učincima na prateće komorbitete dijabetesa. Ti dodatni učinci potakli su znanstvenike da preispitaju njegove mehanizme kako bi se otkrile nove indikacije ovog lijeka. Kod sindroma policističnih jajnika metformin poboljšava ovulaciju i začeće te se koristi prilikom in vitro fertilizacije pacijentica oboljelih od sindroma. Pretpostavka da metformin posjeduje mehanizme koji oponašaju kalorijsku restrikciju koristi se u anti-ageing studijama. Klinički pokazatelji o smanjenoj incidenciji raka kod dijabetičara na terapiji metforminom zainteresirali su znanstvenu javnost te je primjena metformina u terapiji raka danas područje brojnih istraživanja pri čemu se pokušavaju otkriti stanični mehanizmi potencijalnog antitumorskog djelovanja. Sigurnost primjene metformina u bubrežnim bolestima je dokazana, a sprečavanjem oksidativnog stresa metformin ispoljava renoprotektivne učinke.
Abstract (english)
This theoretical thesis presents the pharmacological properties and therapeutic potential of metformin. According to the world and Croatian guidelines for the treatment of type 2 diabetes, metformin is the drug of first choice. The special value of this drug are strong clinical evidence of positive effects on the accompanying comorbidities of diabetes. These additional effects prompted the scientists to re-examine its mechanisms of action to detect new indications of this drug. Metformin improves ovulation and conception, and because of that it is used during in vitro fertilisation in patients suffering from polycystic ovary syndrome. The hypothesis that metformin has mechanisms that mimic caloric restriction is used in anti-ageing studies. Clinical indicators of reduced incidence of cancer in diabetic patients treated with metformin became area of interest in the scientific community and currenty application of metformin in the treatment of cancer is an area of intense research. The safety of metformin in kidney diseases has been demonstrated and by preventing oxidative stress metformin exerts its renoprotective effect.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:717625
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-12-09 12:11:07