prikaz prve stranice dokumenta A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
  Download
PDF 120.47 KB
Scientific paper - Preliminary note / Short communication
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
Acta Pharmaceutica, 63 (2013), 3; 409-418. https://doi.org/10.2478/acph-2013-0023
Perković, Ivana; Rajić Džolić, Zrinka; Zorc, Branka

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Perković, I., Rajić Džolić, Z. & Zorc, B. (2013). A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharmaceutica, 63. (3), 409-418. doi: 10.2478/acph-2013-0023

Perković, Ivana, et al. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica, vol. 63, no. 3, 2013, pp. 409-418. https://doi.org/10.2478/acph-2013-0023

Perković, Ivana, Zrinka Rajić Džolić and Branka Zorc. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica 63, no. 3 (2013): 409-418. https://doi.org/10.2478/acph-2013-0023

Perković, I., Rajić Džolić, Z. and Zorc, B. (2013) 'A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties', Acta Pharmaceutica, 63(3), pp. 409-418. doi: 10.2478/acph-2013-0023

Perković I, Rajić Džolić Z, Zorc B. A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharmaceutica [Internet]. 2013 September 30 [cited 2024 December 23];63(3):409-418. doi: 10.2478/acph-2013-0023

I. Perković, Z. Rajić Džolić and B. Zorc, "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties", Acta Pharmaceutica, vol. 63, no. 3, pp. 409-418, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:609022. [Accessed: 23 December 2024]

Metadata
Title (english)A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
AuthorIvana Perković
AuthorZrinka Rajić Džolić
AuthorBranka Zorc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
Keywords (english)
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 63, no. 3, pp. 409-418
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2013-0023
URN:NBNurn:nbn:hr:163:609022
Publication2013-09-30
Document URLhttp://hrcak.srce.hr/102049
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-14 15:03:21