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Scientific paper - review paper
Kovinski ioni, Alzheimerova bolest i kelacijska terapija
Acta Pharmaceutica, 61 (2011), 1; 1-14. https://doi.org/10.2478/v10007-011-0006-6
Budimir, Ana

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Budimir, A. (2011). Kovinski ioni, Alzheimerova bolest i kelacijska terapija. Acta Pharmaceutica, 61. (1), 1-14. doi: 10.2478/v10007-011-0006-6

Budimir, Ana. "Kovinski ioni, Alzheimerova bolest i kelacijska terapija." Acta Pharmaceutica, vol. 61, no. 1, 2011, pp. 1-14. https://doi.org/10.2478/v10007-011-0006-6

Budimir, Ana. "Kovinski ioni, Alzheimerova bolest i kelacijska terapija." Acta Pharmaceutica 61, no. 1 (2011): 1-14. https://doi.org/10.2478/v10007-011-0006-6

Budimir, A. (2011) 'Kovinski ioni, Alzheimerova bolest i kelacijska terapija', Acta Pharmaceutica, 61(1), pp. 1-14. doi: 10.2478/v10007-011-0006-6

Budimir A. Kovinski ioni, Alzheimerova bolest i kelacijska terapija. Acta Pharmaceutica [Internet]. 2011 March 01 [cited 2024 November 29];61(1):1-14. doi: 10.2478/v10007-011-0006-6

A. Budimir, "Kovinski ioni, Alzheimerova bolest i kelacijska terapija", Acta Pharmaceutica, vol. 61, no. 1, pp. 1-14, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:984971. [Accessed: 29 November 2024]

Metadata
Title (croatian)Kovinski ioni, Alzheimerova bolest i kelacijska terapija
Title (english)Metal ions, Alzheimer’s disease and chelation therapy
AuthorAna Budimir
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of general and inorganic chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
Najnovija istraživanja na polju neurodegeneracije jasno pokazuju da kovinski ioni imaju značajnu ulogu u patogenezi Alzheimerove kao i drugih neurodegenerativnih bolesti. U skladu s ovim spoznajama upotreba kovinskih kelatora predstavlja zanimljiv i inovativan farmakološki pristup daljnjem istraživanju i mogućoj terapiji neurodegenerativnih stanja. U ovom radu ukratko je dan sažetak istraživanja upotrebe kovinskih kelatora u tretmanu Alzheimerove bolesti s posebnim osvrtom na istraživanja analoga 8-hidroksikinolina.
Abstract (english)
In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration represents an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.
Keywords (croatian)
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 61, no. 1, pp. 1-14
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/v10007-011-0006-6
URN:NBNurn:nbn:hr:163:984971
Publication2011-03-01
Document URLhttp://hrcak.srce.hr/63377
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-14 15:10:41