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master's thesis
Povezanost stresa i aktivacije koagulacijskog sustava
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. urn:nbn:hr:163:909046
Kmet, Marta
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medical biochemistry and haematology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Kmet, M. (2017). Povezanost stresa i aktivacije koagulacijskog sustava (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:909046

Kmet, Marta. "Povezanost stresa i aktivacije koagulacijskog sustava." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:163:909046

Kmet, Marta. "Povezanost stresa i aktivacije koagulacijskog sustava." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:163:909046

Kmet, M. (2017). 'Povezanost stresa i aktivacije koagulacijskog sustava', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:909046

Kmet M. Povezanost stresa i aktivacije koagulacijskog sustava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2017 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:909046

M. Kmet, "Povezanost stresa i aktivacije koagulacijskog sustava", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:163:909046

Metadata
TitlePovezanost stresa i aktivacije koagulacijskog sustava
Title (english)Relationship between stress and activation of the coagulation system
AuthorMarta Kmet
MentorNada Vrkić (mentor)
Committee memberNada Vrkić (predsjednik povjerenstva)
Committee memberMarija Grdić Rajković (član povjerenstva)
Committee memberSandra Šupraha Goreta (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Zagreb
Defense date and country2017-06-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract
Dvadesetčetirisatna dežurstva predstavljaju jedan od većih stresora za liječnike jer osim umora i poremećaja cirkadijarnog ritma uključuju odgovornost u donošenju odluka i rad s pacijentima koji nisu uvijek suradljivi. Poznato je da stres na radnom mjestu dovodi do aktivacije koagulacijskog sustava, a nastalo hiperkoagulabilno stanje pogoduje razvoju kardiovaskularnih oštećenja. Cilj ovog rada bio je ispitati utjecaj dvadesetčetirisatnog dežurstva na globalne koagulacijske pretrage: PV, APTV i TV te na koncentraciju fibrinogena i vrijeme fibrinolize. U istraživanju je sudjelovalo 29 liječnika na specijalističkom usavršavanju. Liječnicima je krv uzeta tri puta: prije, tijekom i nakon dežurstva. Rezultati su pokazali da nije došlo do značajne aktivacije koagulacijskog sustava koja bi se odrazila na globalne pretrage i koncentraciju fibrinogena. Međutim, pokazalo se da je vrijeme fibrinolize dobiveno euglobulinskim testom produženo u dva jutarnja mjerenja u odnosu na mijerenje tijekom dežurstva u večernjim satima. Nije jasno u kojoj je mjeri navedena promjena uzrokovana stresnim dežurstvom, a u kojoj fiziološkim oscilacijama u aktivaciji fibrinolize.
Abstract (english)
24-h work shifts are known to be one of the major stressors for physicians because of the circadian rhythm disruption and tiredness. Besides that, they include responsibility in making decisions and working with patients who are not always cooperative. Studies have shown that work stress leads to the activation of the coagulation system, and that the resulting hypercoagulable state favors the development of cardiovascular damage. The aim of this study was to examine the effects of a 24-h work shift on global coagulation parameters: prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT), but also the fibrinogen concentration and fibrinolysis time. The study group included 29 physicians on education. The blood was sampled three times: before, during and after the work shift. Our results have shown that there was no coagulation system activation that would affect global tests and fibrinogen concentration. However, fibrinolysis time obtained with the euglobulin test was extended in two morning measurements compared to the evening measurement. It is not clear if this is caused by work stress or the physiologic oscillations in fibrinolysis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:909046
Study programmeTitle: Medical biochemistry
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra medicinske biokemije (magistar/magistra medicinske biokemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-11-16 12:12:17