Acne vulgaris is a common inflammatory skin disease of the pilosebaceous follicles, especially in adolescents ad young adults. Lesions of acne vulgaris are most commonly found on the face, but also located on the neck, chest, upper back and shoulders. Acne lesions can be inflammatory or noninflammatory. Noninflammatory lesions consist of either open or closed comedones and inflammatory lesions are characterized as papules, pustules or nodules. The pathologic factors involved in development of acne vulgaris are: sebum production, follicular hyperkeratinization, microbial colonization with Propionibacterium acnes and complex inflammatory mechanisms involving both inate and acquired immunity. The treatment of acne vulgaris depends on the severity of the disease. Successful acne therapy must address one or more of the four mechanisms involved in the pathogenesis of acne. This paper describes pharmacologic profil of the topical and systemic drugs used to treat acne vulgaris. It is mostly based on the Guidelines of care for the management of acne vulgaris published in 2016 by the American Academy of Dermatology. Usually used topical acne treatments include benzoyl peroxide, antibiotics, combination antibiotics with benzoyl peroxide, retinoids, retinoid with benzoyl peroxide, retinoid with antibiotic, azelaic acid, salicylic acid, and sulfone agents. Topical treatment of acne vulgaris may be used as monotherapy, in combination with other topical agents or in combination with systemic agents. Systemic therapy includes oral antibiotics, hormonal agents or isotretinoin. The pharmacist has an important role in providing optimal care for patients with acne vulgaris. As the most accessible health professional, pharmacist should first evaluate if self-treatment is appropriate and recommend that patients with severe cases of acne seek further evaluation from a dermatologist. Acne vulgaris has a considerable negative impact on quality of life. The pharmacist may motivate the patient to continue long-term therapy. Also, the pharmacist should provide the patient with clear instructions how and when to take drugs and recommend some OTC products which may prevent or decrease side effects of some prescribed drugs.