Acne is a chronic inflammatory dermatosis which most commonly affects adolescents and young adults. The etiopathogenesis factors of acne are excess sebum production, follicular kyoerkeratinization, follicular reactivity, hormones, microorganisms, inflammation and diet. Predilection sites are the areas of skin with a dense population of sebaceous follicles. There are three main clinical forms of the disease: acne comedonica, acne papulopustulosa and acne conglobata. The disease frequently withdraws in young adulthood. However, it may affect people in middle adulthood as well. The main aim of the treatment is to reduce the symptomes, prevent scarring and relapse. Mild cases are treated locally/topically, whereas severe cases require systemic treatment. Although dietary factors have long been considered irrelevant, the contemporary view is that diet plays a significant role in the incidence of acne and the level od their clinical manifestation. We are presented with the hypothesis of insulin resistance in acne etiology. Emotional stress can exasperate acne (anxiety, frustration, stress). On the other hand, acne can lead to psychological distress in patients, which is of particular importance in adolescence as this age is considered critical in the development of identity (low self-esteem, anger management issues, inhibited social interaction). Acne can be aggravated or initiated by increased androgen levels, particularly in female adolescents. The condition is usually presented as oily skin, acne, increased body/facial hair, excessive hair loss and baldness. It is increasingly considered that positive family anamnesis contributes to the prevalence which is associated with polymorphism in the promotor region of the THF gene, where THF gene is the main driver of the inflammation.