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master's thesis
Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. urn:nbn:hr:163:230605
Bašić, Ane
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Bašić, A. (2017). Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:230605

Bašić, Ane. "Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:163:230605

Bašić, Ane. "Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2017. https://urn.nsk.hr/urn:nbn:hr:163:230605

Bašić, A. (2017). 'Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 05 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:230605

Bašić A. Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2017 [cited 2024 November 05] Available at: https://urn.nsk.hr/urn:nbn:hr:163:230605

A. Bašić, "Farmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:163:230605

Metadata
TitleFarmakoterapijske mogucnosti u lijecenju atopijskog dermatitisa
Title (english)Pharmacotherapeutic options in atopic dermatitis treatment
AuthorAne Bašić
MentorPetra Turčić (mentor)
Committee memberPetra Turčić (predsjednik povjerenstva)
Committee memberMiranda Sertić (član povjerenstva)
Committee memberVišnja Drinovac (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2017-09-06, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Atopijski dermatitis je kronična upalna dermatoza koja pogađa 15 do 30% djece te 1 do 3 % odraslih. Većini oboljelih simptomi se povlače do razdoblja adolescencije, ali bolest može progredirati u astmu ili alergijski rinitis. Bolest je karakterizirana kompleksnom patogenezom koja uključuje kombinaciju genetičkih, imunosnih i okolišnih čimbenika koji posljedično dovode do narušavanja barijerne funkcije kože i neravnoteže imunosnog sustava. Najčešći simptomi su svrbež, crvenilo, edem, suhoća kože, erozije te lihenifikacija. U prevenciji je važna hidratacija kože te izbjegavanje čimbenika koji dovode do pogoršanja. Osnovu terapije čine topikalno primjenjeni kortikosteroidi, a na određenim lokacija preporučuju se lokalni inhibitori kalcineurina. Kod težih oblika bolesti primjenjuju se sistemski imunomodulatori, animikrobni lijekovi, kortikosteroidi i retinoidi. Novi terapijski pristupi su usmjereni na inhibiciju Th2 imunosnog odgovora i redukciju upale te su trenutno u različitim fazama kliničkih ispitivanja.
Abstract (english)
Atopic dermatitis is a chronic inflammatory dermatosis that affects 15 to 30% of children and 1% to 3% of adults. The majority of affected individuals have a resolution of disease by adulthood but it may progress to asthma or allergic rhinitis. The disease is characterized by a complex pathogenesis involving genetic, immunologic and environmental factors which lead to a dysfunctional skin barrier and dysregulation of the immune system. The symptoms often include pruritus, erythema, edema, xerosis, erosions and lichenification. Prevention is focused on skin hydration and avoidance of provocation factors. Topical corticosteroids are the mainstay of therapy and are used for exacerbation management and proactive therapy in selected cases. In certain locations, topical calcineurin inhibitors such as pimecrolimus and tacrolimus are preferred. Systemic therapy options such as immunomodulators, corticosteroids, antimicrobial agents and retinoids are used for severe cases. New therapeutic options are focused on inhibiting Th2 immune response and reduction of inflammation and are currently in different phases of clinical trials.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:230605
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-01-25 15:01:21