prikaz prve stranice dokumenta Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova
  Download
PDF 1.37 MB
master's thesis
Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. urn:nbn:hr:163:391772
Curiš, Hrvoje
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of general and inorganic chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Curiš, H. (2015). Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:391772

Curiš, Hrvoje. "Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:391772

Curiš, Hrvoje. "Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:391772

Curiš, H. (2015). 'Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 19 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:391772

Curiš H. Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2015 [cited 2024 May 19] Available at: https://urn.nsk.hr/urn:nbn:hr:163:391772

H. Curiš, "Promjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:163:391772

Metadata
TitlePromjena glikozilacije alfa1-kiselog glikoproteina - utjecaj na konstantu vezanja odabranih lijekova
Title (english)Change in glycosylation of alpha1-acid glycoprotein - effect on the binding constants of selected drugs
AuthorHrvoje Curiš
MentorMario Gabričević (mentor)
Committee memberMario Gabričević
Committee memberErim Bešić
Committee memberTin Weitner
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of general and inorganic chemistry)
Zagreb
Defense date and country2015-07-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom radu ispitivan je efekt promjene konstante vezanja imatiniba, dipiridamola, morfina, imipramina i propranolola na α1-kiseli glikoprotein uslijed promjene u uzorku njegove glikozilacije. Tehnika korištena u ispitivanju bila je fluorescencijska spektrofotometrija. Rezultati ispitivanja ukazuju na to da desijalinizacija α1-kiselog glikoproteina uzrokuje promjenu u konstantama kemijske ravnoteže između odabranih lijekova i α1-kiselog glikoproteina. Kod imatiniba, imipramina i propranolola desijalinizacija α1-kiselog glikoproteina će uzrokovati smanjenje konstante kemijske ravnoteže između lijekova i α1-kiselog glikoproteina dok će kod dipiridamola i morfina efekt biti suprotan i nakon desijalinizacije α1-kiselog glikoproteina oni će se jače vezati za desijaliniziranu formu α1-kiselog glikoproteina.
Abstract (english)
In this work an effect of change in glycosylation pattern of α1-acid glycoprotein on the binding constants of imatinib, dipyridamole, morphine, imipramine and propranolol was examined by spectrofluorometric measurements. Results indicate that there is an effect of desialylation of α1-acid glycoprotein on binding constants of selected drugs. Desialylation of α1-acid glycoprotein will reduce the binding constant for imatinib, imipramine and propranolol. On the other hand, dipyridamole and morphine will bind with a higher binding constant to α1-acid glycoprotein after its desialylation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:391772
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-01-20 12:15:24