prikaz prve stranice dokumenta Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening
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Scientific paper - Original scientific paper
Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening
Croatica Chemica Acta, 83 (2010), 2; 151-161. urn:nbn:hr:163:634730
Perković, Ivana; Butula, Ivan; Rajić, Zrinka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Zorc, Branka

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Perković, I., Butula, I., Rajić, Z., Hadjipavlou Litina, D., Pontiki, E. & Zorc, B. (2010). Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening. Croatica Chemica Acta, 83. (2), 151-161. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:634730

Perković, Ivana, et al. "Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening." Croatica Chemica Acta, vol. 83, no. 2, 2010, pp. 151-161. https://urn.nsk.hr/urn:nbn:hr:163:634730

Perković, Ivana, Ivan Butula, Zrinka Rajić, Dimitra Hadjipavlou Litina, Eleni Pontiki and Branka Zorc. "Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening." Croatica Chemica Acta 83, no. 2 (2010): 151-161. https://urn.nsk.hr/urn:nbn:hr:163:634730

Perković, I., et al. (2010) 'Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening', Croatica Chemica Acta, 83(2), pp. 151-161. Available at: https://urn.nsk.hr/urn:nbn:hr:163:634730 (Accessed 27 December 2024)

Perković I, Butula I, Rajić Z, Hadjipavlou Litina D, Pontiki E, Zorc B. Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening. Croatica Chemica Acta [Internet]. 2010 July 15 [cited 2024 December 27];83(2):151-161. Available at: https://urn.nsk.hr/urn:nbn:hr:163:634730

I. Perković, I. Butula, Z. Rajić, D. Hadjipavlou Litina, E. Pontiki and B. Zorc, "Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening", Croatica Chemica Acta, vol. 83, no. 2, pp. 151-161, July 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:634730. [Accessed: 27 December 2024]

Metadata
Title (english)Novel ureidoamides derived from amino acids: synthesis and preliminary biological screening
AuthorIvana Perković
AuthorIvan Butula
MBZ: 6372
AuthorZrinka Rajić
AuthorDimitra Hadjipavlou-Litina
AuthorEleni Pontiki
AuthorBranka Zorc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
A series of novel amino acid ureidoamides 4a-o were prepared from N-(1-benzotriazolecarbonyl)- amino acid chloride 3, derived from L-alanine, L-valine, L-leucine, D-phenylglycine and L-phenylalanine, and the corresponding aminoalcohols (2-amino-1-ethanol, 3-amino-1-propanol and 5-amino-1-pentanol). The compounds were fully characterized by standard spectroscopic methods (IR, 1H and 13C NMR) and their structure was confirmed by elemental analysis. Antioxidant screenings (interaction with 1,1-diphenyl-2-picrylhydrazyl, soybean lipoxygenase inhibition activity, inhibition of linoleic acid lipid peroxidation) revealed that the prepared compounds possessed only modest activity. On the other hand, no significant antiproliferative activity against five human cell lines and very weak antimicrobial activity against several bacteria and fungi were detected.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 83, no. 2, pp. 151-161
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:634730
Publication2010-07-15
Document URLhttps://hrcak.srce.hr/56018
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-02-14 13:29:54