prikaz prve stranice dokumenta Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives
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Scientific paper - Original scientific paper
Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives
Acta Pharmaceutica, 56 (2006), 4; 463-470. urn:nbn:hr:163:769901
Ballian Krznar, Davorka; Filipović-Grčić, Jelena; Zorc, Branka; Zovko, Marijana

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Ballian Krznar, D., Filipović Grčić, J., Zorc, B. & Zovko, M. (2006). Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives. Acta Pharmaceutica, 56. (4), 463-470. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:769901

Ballian Krznar, Davorka, et al. "Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives." Acta Pharmaceutica, vol. 56, no. 4, 2006, pp. 463-470. https://urn.nsk.hr/urn:nbn:hr:163:769901

Ballian Krznar, Davorka, Jelena Filipović Grčić, Branka Zorc and Marijana Zovko. "Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives." Acta Pharmaceutica 56, no. 4 (2006): 463-470. https://urn.nsk.hr/urn:nbn:hr:163:769901

Ballian Krznar, D., et al. (2006) 'Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives', Acta Pharmaceutica, 56(4), pp. 463-470. Available at: https://urn.nsk.hr/urn:nbn:hr:163:769901 (Accessed 23 December 2024)

Ballian Krznar D, Filipović Grčić J, Zorc B, Zovko M. Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives. Acta Pharmaceutica [Internet]. 2006 December 01 [cited 2024 December 23];56(4):463-470. Available at: https://urn.nsk.hr/urn:nbn:hr:163:769901

D. Ballian Krznar, J. Filipović Grčić, B. Zorc and M. Zovko, "Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives", Acta Pharmaceutica, vol. 56, no. 4, pp. 463-470, December 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:769901. [Accessed: 23 December 2024]

Metadata
Title (english)Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives
Title (croatian)Oslobađanje celekoksiba iz mukoadhezivnih diskova s polimerima poliaspartamidnog tipa
AuthorDavorka Ballian Krznar
AuthorJelena Filipović-Grčić
AuthorBranka Zorc
AuthorMarijana Zovko
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly,-(N-2-hydroxyethyl-DL-aspartamide) (PHEA, 1) and its thiolated analogue poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.
Abstract (croatian)
Pripravljeni su i karakterizirani mukoadhezivni diskovi s celekoksibom kao lipofilnom modelnom supstancijom. Kao ekscipiensi uporabljena su dva polimera poliaspartamidnog tipa, poli[α,β-(N-2-hidroksietil-DL-aspartamid) (PHEA, 1) i njegov tiolirani analog poli[α,β-(N-2-hidroksietil-DL-aspartamid)]-poli[α,β-(N-2-tioetil-DL-aspartamid)] kopolimer (PHTA, 2a,b), te dva komercijalno dostupna polimera Carbopol 934P i hidroksipropilmetilceluloza 4000. Najbolji profil oslobađanja celekoksiba postignut je iz diskova sastavljenih od tiomera 2b i Carbopola 934P u masenom omjeru 1:1.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 56, no. 4, pp. 463-470
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:769901
Publication2006-12-01
Document URLhttps://hrcak.srce.hr/4608
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-02-14 13:50:24