prikaz prve stranice dokumenta Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
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Scientific paper - Original scientific paper
Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
Acta Pharmaceutica, 55 (2005), 2; 169-176. urn:nbn:hr:163:491468
Zovko, Marijana; Barbarić, Monika; Zorc, Branka; Hafner, Anita; Filipović-Grčić, Jelena

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Zovko, M., Barbarić, M., Zorc, B., Hafner, A. & Filipović Grčić, J. (2005). Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharmaceutica, 55. (2), 169-176. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:491468

Zovko, Marijana, et al. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica, vol. 55, no. 2, 2005, pp. 169-176. https://urn.nsk.hr/urn:nbn:hr:163:491468

Zovko, Marijana, Monika Barbarić, Branka Zorc, Anita Hafner and Jelena Filipović Grčić. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica 55, no. 2 (2005): 169-176. https://urn.nsk.hr/urn:nbn:hr:163:491468

Zovko, M., et al. (2005) 'Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates', Acta Pharmaceutica, 55(2), pp. 169-176. Available at: https://urn.nsk.hr/urn:nbn:hr:163:491468 (Accessed 23 December 2024)

Zovko M, Barbarić M, Zorc B, Hafner A, Filipović Grčić J. Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharmaceutica [Internet]. 2005 June 01 [cited 2024 December 23];55(2):169-176. Available at: https://urn.nsk.hr/urn:nbn:hr:163:491468

M. Zovko, M. Barbarić, B. Zorc, A. Hafner and J. Filipović Grčić, "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates", Acta Pharmaceutica, vol. 55, no. 2, pp. 169-176, June 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:491468. [Accessed: 23 December 2024]

Metadata
Title (english)Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
Title (croatian)Sinteza konjugata fenoprofena i gemfibrozila s kopolimerom stirena i maleinske kiseline
AuthorMarijana Zovko
AuthorMonika Barbarić
AuthorBranka Zorc
AuthorAnita Hafner
AuthorJelena Filipović-Grčić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.
Abstract (croatian)
U radu je opisana sinteza polimer-lijek konjugata polazeći od kopolimera stirena i anhidrida maleinske kiseline (SMA) i fenoprofena, odnosno gemfibrozila, ljekovitih tvari s kratkim vremenom zadržavanja u plazmi. Fenoprofen i gemfibrozil su prvo prevedeni u 2-aminoetilamide, koji su zbog slobodne amino skupine mogli reagirati s anhidridnim prstenovima u SMA. Modifikacijom tipa i vrste supstitucije pripravljeni su lipofilni i hidrofilni konjugati. Udio vezanog lijeka u konjugatima bio je između 17 and 47%.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 55, no. 2, pp. 169-176
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:491468
Publication2005-06-01
Document URLhttps://hrcak.srce.hr/16754
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-02-14 14:28:28