prikaz prve stranice dokumenta Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
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Scientific paper - Original scientific paper
Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
Croatica Chemica Acta, 63 (1991), 4; 565-578. urn:nbn:hr:163:408285
Zorc, Branka; Karlović, G.; Butula, Ivan

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Zorc, B., Karlović, G. & Butula, I. (1991). Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis. Croatica Chemica Acta, 63. (4), 565-578. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:408285

Zorc, Branka, et al. "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis." Croatica Chemica Acta, vol. 63, no. 4, 1991, pp. 565-578. https://urn.nsk.hr/urn:nbn:hr:163:408285

Zorc, Branka, G. Karlović and Ivan Butula. "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis." Croatica Chemica Acta 63, no. 4 (1991): 565-578. https://urn.nsk.hr/urn:nbn:hr:163:408285

Zorc, B., Karlović, G. and Butula, I. (1991) 'Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis', Croatica Chemica Acta, 63(4), pp. 565-578. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408285 (Accessed 23 December 2024)

Zorc B, Karlović G, Butula I. Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis. Croatica Chemica Acta [Internet]. 1991 March 26 [cited 2024 December 23];63(4):565-578. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408285

B. Zorc, G. Karlović and I. Butula, "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis", Croatica Chemica Acta, vol. 63, no. 4, pp. 565-578, March 1991. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408285. [Accessed: 23 December 2024]

Metadata
Title (english)Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
AuthorBranka Zorc
AuthorG. Karlović
AuthorIvan Butula
MBZ: 6372
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The use of the 1-benzotriazolylearbonyl-(Bte)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-(Z)-group. N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 63, no. 4, pp. 565-578
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:408285
Publication1991-03-26
Document URLhttps://hrcak.srce.hr/176511
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-02-22 14:17:27