prikaz prve stranice dokumenta A journey through mitogen-activated protein kinase and ochratoxin A interactions
  Download
PDF 265.52 KB
Scientific paper - review paper
A journey through mitogen-activated protein kinase and ochratoxin A interactions
Arhiv za higijenu rada i toksikologiju, 60 (2009), 4; 449-456. https://doi.org/10.2478/10004-1254-60-2009-1969
Rumora, Lada; Žanić Grubišić, Tihana

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Rumora, L. & Žanić Grubišić, T. (2009). A journey through mitogen-activated protein kinase and ochratoxin A interactions. Arhiv za higijenu rada i toksikologiju, 60. (4), 449-456. doi: 10.2478/10004-1254-60-2009-1969

Rumora, Lada and Tihana Žanić Grubišić. "A journey through mitogen-activated protein kinase and ochratoxin A interactions." Arhiv za higijenu rada i toksikologiju, vol. 60, no. 4, 2009, pp. 449-456. https://doi.org/10.2478/10004-1254-60-2009-1969

Rumora, Lada and Tihana Žanić Grubišić. "A journey through mitogen-activated protein kinase and ochratoxin A interactions." Arhiv za higijenu rada i toksikologiju 60, no. 4 (2009): 449-456. https://doi.org/10.2478/10004-1254-60-2009-1969

Rumora, L. and Žanić Grubišić, T. (2009) 'A journey through mitogen-activated protein kinase and ochratoxin A interactions', Arhiv za higijenu rada i toksikologiju, 60(4), pp. 449-456. doi: 10.2478/10004-1254-60-2009-1969

Rumora L, Žanić Grubišić T. A journey through mitogen-activated protein kinase and ochratoxin A interactions. Arhiv za higijenu rada i toksikologiju [Internet]. 2009 December 22 [cited 2024 December 28];60(4):449-456. doi: 10.2478/10004-1254-60-2009-1969

L. Rumora and T. Žanić Grubišić, "A journey through mitogen-activated protein kinase and ochratoxin A interactions", Arhiv za higijenu rada i toksikologiju, vol. 60, no. 4, pp. 449-456, December 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:248928. [Accessed: 28 December 2024]

Metadata
Title (english)A journey through mitogen-activated protein kinase and ochratoxin A interactions
Title (croatian)Putovanje kroz interakcije proteinskih kinaza aktiviranih mitogenima i okratoksina A
AuthorLada Rumora
AuthorTihana Žanić Grubišić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
Ochratoxin A (OTA) is a ubiquitous mycotoxin with potential nephrotoxic, carcinogenic, and cytotoxic action. It has been proposed that OTA might be involved in the development of Balkan endemic nephropathy, which is associated with an increased risk of urinary tract tumours, and of other forms of interstitial nephritis. Cell susceptibility to OTA mainly depends on mycotoxin concentrations, duration of exposure, and intracellular molecular and genetic context. OTA can affect a cell by stimulating or inhibiting certain signalling pathways such as mitogen-activated protein kinase (MAPK). Three major mammalian MAPKs have been described: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. All MAPKs regulate diverse cellular programmes, but in most cases ERKs have been linked to cell survival, while JNKs, and p38 MAPKs have been implicated in cell death by apoptosis. This review looks into OTA-mediated MAPK activation and its effects.
Abstract (croatian)
Okratoksin A (OTA) posvuda je prisutan mikotoksin za koji se smatra da je potencijalno nefrotoksičan i karcinogen, a može uzrokovati i smrt stanice. OTA se smatra mogućim uzročnikom balkanske endemske nefropatije koju karakterizira povećani rizik od razvoja tumora mokraćnog sustava te različitih drugih vrsta intersticijskog nefritisa. Osjetljivost stanice naspram OTA ovisi ponajprije o koncentraciji mikotoksina, vremenu izloženosti i o unutarstaničnome molekularnom i genskom sklopu. OTA može djelovati na stanicu tako što potiče ili inhibira određene signalne putove u stanici poput puta proteinskih kinaza aktiviranih mitogenima (MAPK). Tri glavne MAPK u sisavaca su proteinska kinaza regulirana izvanstaničnim signalima (ERK), kinaza koja fosforilira N-kraj transkripcijskog faktora c-Jun (JNK) i p38 MAPK. Svi članovi porodice MAPK reguliraju različite stanične programe, s time da ERK najčešće stimuliraju preživljavanje stanica, dok JNK i p38 MAPK najčešće uzrokuju umiranje stanica apoptozom. U ovome smo preglednom članku prikazali na koji način stanice odgovaraju na aktivaciju MAPK koju potiče OTA.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 60, no. 4, pp. 449-456
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.2478/10004-1254-60-2009-1969
URN:NBNurn:nbn:hr:163:248928
Publication2009-12-22
Document URLhttps://hrcak.srce.hr/45391
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-05-11 13:31:16