| Abstract (croatian) | Cinnamic acid (3-phenylpropenoic or phenylacrylic acid) and its derivatives
occur naturally in a number of plants. Th ey are precursors in the biosynthetic
pathways of many alkaloids, aromatic amino acids, phenylpropanoids,
styrenes, stilbenes, coumarins, lignins and fl avonoids, and are present in
various essential oils, gums and balsams. Cinnamic acid derivatives are used in
large quantities in the food, cosmetic and pharmaceutical industries. In addition,
they possess a variety of pharmacological activities: antimicrobial, antitubercular,
antioxidative, antimicrobial, antimalarial, antiviral, antidiabetic,
hepatoprotective, antidepressant, anxiolytic, hypolipemic, anti-infl ammatory
and cytostatic activities. Several drugs with cinnamic acid motifs are used in
modern therapy (panobinostat, belinostat, cinanserin, tranilast, ozagrel and
entacapone). |
