Title Liječenje migrenske glavobolje
Title (english) Migraine Headache Treatment
Author Petra Franjković
Mentor Lidija Bach-Rojecky (mentor)
Committee member Lidija Bach-Rojecky (predsjednik povjerenstva)
Committee member Višnja Drinovac (član povjerenstva)
Committee member Živka Juričić (član povjerenstva)
Granter University of Zagreb Faculty of Pharmacy and Biochemistry (Department of pharmacology) Zagreb
Defense date and country 2018-05-18, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Pharmacy Pharmacy
Abstract Migrenska glavobolja je složeni i čest neurološki poremećaj te jedan od najčešćih uzroka onesposobljenja u svijetu. Karakterizirana je unilateralnim, pulsirajućim glavoboljama i popraćena je nizom simptoma kao što su mučnina, povraćanje, povećana osjetljivost na kretanje, svjetlost, zvukove, mirise i hranu. Kod približno jedne trećine pacijenata s migrenom napadaji su povezani s neurološkim deficitima koji uključuju kortikalne perturbacije, što se naziva migrenskom aurom.
Patofiziologija migrene je složena i još uvijek nije do kraja razjašnjena. Prema dosadašnjim saznanjima središnje mjesto u patogenezi migrene ima aktivacija i senzitizacija trigeminovaskularnog sustava što rezultira glavoboljama karakterističnim za migrenu.
Liječenje migrene može biti usmjereno na prekidanje boli (akutno/abortivno) ili na prevenciju napadaja. Akutna terapija uključuje analgetike, antiemetike, ergot alkaloide i triptane; a preventivna uključuje antihipertenzive, antidepresive, antiepileptike, nesteroidne protuupalne lijekove, onabotulinum toksin A i nefarmakološke pristupe. Određenim pacijentima s čestim ili teškim glavoboljama potrebne su obje strategije liječenja. Preventivni lijekovi često se koriste u kombinaciji s drugim terapijskim opcijama i dio su sveobuhvatnog individualiziranog liječenja.
Preventivnim liječenjem nastoji se smanjiti frekvenciju napadaja migrene, smanjiti ozbiljnost i trajanje napadaja, poboljšati odgovor na akutnu terapiju te poboljšati funkcioniranje i smanjiti onesposobljenje oboljelih. Osim toga, učinkovito preventivno liječenje dovodi i do smanjenja troškova u sustavu zdravstvene zaštite.
Danas glavnu antimigrensku terapiju predstavljaju triptani koji kod mnogih pacijenata ne postižu zadovoljavajuće učinke te su istraživanja usmjerena na druge neuropeptide i receptore za koje je otkriveno da sudjeluju u patofiziologiji migrene.
Abstract (english) Migraine is a complicated, multifactoral neurological disorder that represents one of the most common causes of disability in the world. It is characterized by unilateral, pulsating headaches and is accompanied by various symptoms such as nausea, vomiting, increased sensitivity to motion, light, sounds, smells and food. Approximately one third of migraine patients experience neurological deficits, such as cortical pertubations, which is called a migraine aura.
Migraine patophysiology is complicated and not yet fully understood. According to current knowledge, the main event in migraine patophysiology is activation and sesitisation of the trigeminovascular system which results in typical migraine headaches.
Migraine treatment can be focused towards diminishing pain (acute/abortive) or to prevent the attack altogether. Acute therapy includes analgesics, antiemetics, ergot alcaloids and triptans; whereas preventive therapy includes antihypertensives, antidepressants, antiepileptics, non-steroid antiinflammatory drugs, onabotulinum toxin A and various non-pharmacological approaches. Certain patients that have a high frequency or high intensity headaches require both therapeutic strategies. Preventive drugs are often combined with other therapeutic options and are a part of the wholesale individualised therapy approach.
Preventive treatment is used to reduce the frequency of migraine attacks, their severity and duration, to improve the response to acute therapy and to increase functionality and decrease disability in suffering patients. Furthemore, effective treatment leads to reduced healthcare costs.
Today, triptans represent the main antimigrenic therapy line that do not show satisfying responses in a lot of paitients, which warrants futher research into other neuropeptides and receptors discovered to be a part of the migraine pathophysiology.
Keywords
migrena
liječenje migrene
akutna migrena
kronična migrena
trigeminovaskularni sustav
triptani
CRGP
CGRP receptor
Keywords (english)
migraine
migraine treatment
acute migraine
chronic migraine
trigeminovascular system
triptans
CRGP
CGRP receptor
Language croatian
URN:NBN urn:nbn:hr:163:314865
Study programme Title: Pharmacy Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2018-12-12 12:16:09