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master's thesis
Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:798789
Bovan, Srećko
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Bovan, S. (2021). Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:798789

Bovan, Srećko. "Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:798789

Bovan, Srećko. "Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:798789

Bovan, S. (2021). 'Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije', Master's thesis, University of Zagreb, Faculty of Science, accessed 05 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:798789

Bovan S. Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 May 05] Available at: https://urn.nsk.hr/urn:nbn:hr:217:798789

S. Bovan, "Ekspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:798789

Metadata
TitleEkspresija gena za moždani neurotrofni čimbenik i katehol-O-metil transferazu u leukocitima ispitanika oboljelih od demencije
Title (english)Brain-derived neurotrophic factor and catechol-O-methyl transferase gene expression in leukocytes of subjects with dementia
AuthorSrećko Bovan
MentorMatea Nikolac Perković (mentor)
MentorDubravka Hranilović (sumentor)
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberJulija Erhardt (član povjerenstva)
Committee memberZoran Marčić (član povjerenstva)
Committee memberSandra Hudina (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2021-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Demencija je sindrom uzrokovan oštećenjima u središnjem živčanom sustavu koja rezultiraju poremećajem kognitivnih sposobnosti pri očuvanoj svijesti. Smatra se da je dob glavni čimbenik rizika za razvoj demencije, a s obzirom na starenje svjetske populacije predstavlja sve veći problem za društvo. Moždani neurotrofni čimbenik (BDNF) je član skupine neurotrofina koji u živčanom sustavu sudjeluje u neurogenezi i drugim neurotrofičnim i neuromodulatornim aktivnostima. Katehol-O-metiltransferaza (COMT) je enzim koji je ključan u metabolizmu kateholaminskih neurotransmitera. Cilj ovog rada je istražiti postoji li povezanost razine ekspresije gena BDNF i COMT u stanicama periferne krvi s razvojem demencije i provjeriti može li se razina ekspresije povezati i sa stupnjem kognitivnog oštećenja kod ispitanika s dijagnozom Alzheimerove bolesti ili blagog kognitivnog poremećaja. Rezultati su pokazali da je razina ekspresije gena BDNF značajno manja kod ispitanika s Alzheimerovom bolešću u odnosu na ispitanike s blagim kognitivnim poremećajem. Razina ekspresije gena BDNF povezana je i s razinom kognitivnog oštećenja, što potvrđuje značajna korelacija s rezultatima kognitivnih testova. U slučaju ekspresije gena COMT rezultati nisu potvrdili očekivanu povezanost s razvojem demencije, odnosno s oštećenjima kognitivnih sposobnosti.
Abstract (english)
Dementia is a syndrome caused by damage to the central nervous system that results in impaired cognitive abilities with preserved consciousness. Age is considered to be a major risk factor for the development of dementia, and due to the aging of the world’s population it presents an increasing problem for society. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that participates in neurogenesis and other neurotrophic and neuromodulatory activities in the nervous system. Catechol-O-methyltransferase (COMT) is an enzyme that is crucial in the metabolism of catecholamines. The aim of this study was to investigate the association of BDNF and COMT expression levels in peripheral blood cells with the development of dementia and to examine whether the expression level of these two genes could be associated with the degree of cognitive impairment in subjects diagnosed with Alzheimer's disease or mild cognitive impairment. The results showed that the level of BDNF expression was significantly lower in subjects with Alzheimer’s disease compared to subjects with mild cognitive impairment. BDNF gene expression levels were also associated with the level of cognitive impairment, which was confirmed by a significant correlation with the results of screening tests for cognitive impairment. In the case of COMT gene expression, the results did not confirm the expected association with the development of dementia, or with impairment of cognitive abilities.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:798789
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-10-14 13:02:17