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doctoral thesis
Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:094445
Kostanjevečki, Petra
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Kostanjevečki, P. (2021). Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:094445

Kostanjevečki, Petra. "Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:094445

Kostanjevečki, Petra. "Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:094445

Kostanjevečki, P. (2021). 'Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:094445

Kostanjevečki P. Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:094445

P. Kostanjevečki, "Multirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:094445

Metadata
TitleMultirezidualna analiza i biogeokemijsko ponašanje opioidnih analgetika u vodenom okolišu
Title (english)Multiresidue analysis and biogeochemical behaviour of opioid analgesics in the aquatic environment
AuthorPetra Kostanjevečki
MentorSenka Terzić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberIrena Brčić Karačonji (član povjerenstva)
Committee memberVlasta Drevenkar (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2021-10-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Opioidni analgetici su psihoaktivne tvari koje nakon primjene dospijevaju u otpadne vode putem ljudskih izlučevina. U okviru ove disertacije razvijene su analitičke metode za multirezidualno određivanje tragova 27 terapijskih opioida i njihovih metabolita u otpadnim i površinskim vodama upotrebom vezanog sustava tekućinske kromatografije i spektrometrije masa. Razvijene metode primijenjene su za istraživanje njihove rasprostranjenosti i biogeokemijskog ponašanja u vodenom okolišu. Ukupna koncentracija opioida u otpadnim vodama Grada Zagreba premašivala je 1 000 ng L-1. Najzastupljeniji predstavnici bili su tramadol i metadon. Budući da se njihovo uklanjanje u uređajima za pročišćavanje otpadnih voda pokazalo neučinkovitim, istraženi su alternativni postupci, uključujući biološku razgradnju adaptiranim mješovitim mikrobnim kulturama i abiotičku razgradnju ozoniranjem. Ozoniranjem je uklonjeno do 90 % roditeljskih spojeva, a biološkom razgradnjom do 82 % uz proporcionalno smanjenje toksičnosti za alge. Međutim, i biotičkom i abiotičkom razgradnjom istraženih spojeva nastala je znatna količina stabilnih transformacijskih produkata što treba uzeti u obzir kod sveoubuhvatne procjene njihova utjecaja na okoliš.
Abstract (english)
Opioid analgesics are a group of psychoactive substances which enter the aquatic environment primarily via human excretion. In this thesis, multiresidue analytical methods for the determination of trace levels of 27 therapeutic opioids in wastewater and surface water matrices were developed, using liquid chromatography-tandem mass spectrometry. These methods were applied to study the occurrence and biogeochemical behaviour of the selected opioids in the aquatic environment. The total concentration of investigated opioids in wastewater of the city of Zagreb exceeded 1 000 ng L-1, with tramadol and methadone being the most prominent ones. Due to their rather inefficient elimination in wastewater treatment plants, two alternative procedures, including biological degradation with enriched mixed microbal cultures and ozonation were investigated. An improved removal of up to 90% and 82% was achieved in the ozonation and biodegradation experiments, respectively, with a proportional decrease of toxicity to algae. However, degradation of parent compounds was associated with the formation of stabile transformation products, which should be taken into account when assessing the overall impact on the environment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:094445
Promotion2021
ProjectNumber: IP-2014-09-7031
Title: Sveoubuhvatna procjena ponašanja i sudbine farmaceutski aktivnih tvari u okolišu: makrolidni antibiotici i opioidni analgetici
Title: Comprehensive assessment of the environmental behaviour and fate of pharmaceutically active contaminants: macrolide antibiotics and opioid analgesics
Acronym: COMPASS
Leader: Senka Terzić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
ProjectNumber: IP-2019-04-9519
Title: Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija
Title: Investigation of Pharmaceutical Exposome in Freshwater Organisms – Risk Assessment and Prioritization
Acronym: PHARMA-RISK
Leader: Senka Terzić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent162 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-11-04 16:33:28