prikaz prve stranice dokumenta Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega
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master's thesis
Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega
Zagreb: University of Zagreb, Faculty of Science, 2012. urn:nbn:hr:217:609663
Kutle, Ivana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Kutle, I. (2012). Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:609663

Kutle, Ivana. "Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega." Master's thesis, University of Zagreb, Faculty of Science, 2012. https://urn.nsk.hr/urn:nbn:hr:217:609663

Kutle, Ivana. "Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega." Master's thesis, University of Zagreb, Faculty of Science, 2012. https://urn.nsk.hr/urn:nbn:hr:217:609663

Kutle, I. (2012). 'Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:609663

Kutle I. Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2012 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:609663

I. Kutle, "Povezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:217:609663

Metadata
TitlePovezanost regije glavnog sustava tkivne podudarnosti s karcinomom bubrega
Title (english)Association of the Human Leukocyte Antigen region with renal carcinoma
AuthorIvana Kutle
MentorZorana Grubić (mentor)
MentorAna Galov (mentor)
Committee memberAna Galov (predsjednik povjerenstva)
Committee memberZorana Grubić (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
Committee memberZoran Tadić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2012-12-14, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U ovom radu analizirani su geni i aleli HLA-A, -B i -DRB1 te aleli mikrosatelita TNFa, TNFb i TNFd među 62 nesrodna bolesnika s karcinomom bubrega. Utvrđeno je da nema statistički značajne razlike u učestalosti alela i gena HLA između bolesničke i kontrolne skupine. Podjelom bolesničke skupine s obzirom na veličinu i gradus tumora te zahvaćenost limfnih čvorova tumorom, uočene razlike u učestalosti gena HLA-B*27 (p=0,0073), -DRB1*12 (p=0,0492) i -B*08 (p=0,0441) gube se korigiranjem vrijednosti p, dok bolesnici s karcinomom gradusa 4 pokazuju povećanu učestalost gena HLA-DRB*13 (p=0,0394) i nakon korigiranja u odnosu na kontrolu i skupine bolesnika sa gradusima 2 i 3. Nije uočena razlika u učestalosti alela TNFa i TNFd u skupini bolesnika u usporedbi s kontrolom za razliku od alela TNFb kod kojeg je uočena značajno veća učestalost TNFb-5 (p=3,7x10-7), te smanjena učestalost TNFb-3 (p=0,0002) kod bolesnika. Također TNFb-5 se pojavljuje češće kod bolesnika s tumorom >7 cm i sa gradusom 4, dok je učestalost TNFb-3 u obje skupine značajno smanjena u odnosu na kontrolu. Iz uočenih razlika bi se TNFb-5 mogao smatrati alelom podložnosti, a TNFb-3 zaštitnim alelom u nastanku karcinoma bubrega.
Abstract (english)
In this study, we analyzed HLA-A, -B and -DRB1 genes and alleles and TNFa, TNFb and TNFd microsatellite alleles among 62 unrelated patients with renal carcinoma. No statistically significant difference was found in HLA genes and alleles frequency among patients with renal carcinoma in comparison to controls. Comparison which took into account size, tumor gradus and lymph node metastasis, revealed differences in the frequency of HLA-B*27 (p=0.0073), -DRB1*12 (p=0.0492) and -B*08 (p=0.0441) but only before the p value correction. Patients with gradus 4 showed a significant increase of HLA-DRB1*13 frequency (p=0.0394) in comparison to controls and patients with gradus 2 and 3 even after p value correction. There was no difference in the frequency of TNFa and TNFd alleles among patients in comparison to controls as opposed to TNFb locus for which a higher frequency of TNFb-5 (p=3.7X10-7), and reduced frequency of TNFb-3 (p=0.0002) among patients was observed. TNFb-5 allele occurs more frequently in patients with tumors >7 cm and gradus 4, while the frequency of TNFb-3 in both subgroups shows a decrease compared to controls. The observed difference leads to conclusion that TNFb-5 could infer susceptibility and TNFb-3 protection in the development of renal carcinoma.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:609663
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-02 09:16:36