In this diploma thesis, the preparation of three new lipophilic aliphatic triazole derivatives of manosylated desmuramyl dipeptide, L-Ala-D-isoGln, were described. In the convergent synthesis approach, three subunits were prepared separately: the dipeptide, the aliphatic triazole amine, and the mannose subunit, which were then interconnected by amide bonds. Boc-L-AlaD-Glu(OBn) was prepared as the starting dipeptide from the corresponding protected amino acids. Aliphatic triazole subunits were prepared by click reaction, copper(I) catalyzed azidealkyne cycloaddition (CuAAC) of Boc-protected propargylamine and the corresponding azides, hexadecyl-azide and 2-(adamant-1-yl)ethyl-azide. After the removal of Boc, the resulting aliphatic triazole amines and the previously prepared dodecyl analog were attached by an amide bond to the α-carboxyl group of the dipeptide Boc-L-Ala-D-Glu(OBn). The benzyl-protected mannose subunit with an acetyl linker was prepared by hydrolysis of the corresponding ester. After removal of Boc-protection group aliphatic triazole derivatives of desmuramyl dipeptide were coupled through the carboxyl group of the mannose subunit and the amino groups of alanine. In the last reaction step, all benzyl protecting groups were removed by the catalytic hydrogenolysis reaction and the target molecules of this work were successfully prepared with the final goal of testing their in vivo adjuvant activity.