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doctoral thesis
Priprava i biološka evaluacija novih hidroksipiridinonskih derivata
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:798402
Dandić, Andrea
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Dandić, A. (2022). Priprava i biološka evaluacija novih hidroksipiridinonskih derivata (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:798402

Dandić, Andrea. "Priprava i biološka evaluacija novih hidroksipiridinonskih derivata." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:798402

Dandić, Andrea. "Priprava i biološka evaluacija novih hidroksipiridinonskih derivata." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:798402

Dandić, A. (2022). 'Priprava i biološka evaluacija novih hidroksipiridinonskih derivata', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:798402

Dandić A. Priprava i biološka evaluacija novih hidroksipiridinonskih derivata [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:798402

A. Dandić, "Priprava i biološka evaluacija novih hidroksipiridinonskih derivata", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:798402

Metadata
TitlePriprava i biološka evaluacija novih hidroksipiridinonskih derivata
Title (english)Preparation and biological evaluation of novel hydroxypiridinone derivatives
AuthorAndrea Dandić
MentorVesna Petrović-Peroković (mentor)
Committee memberĐani Škalamera (predsjednik povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberRosana Ribić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-04-01, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
U ovoj doktorskoj disertaciji opisana je priprava novih derivata N-aril-3-hidroksipiridin-4-ona koji se razlikuju po strukturi supstituenata vezanih u meta- i para-položaj arilnog dijela molekule. Reakcije su provedene zagrijavanjem vodenih otopina polaznih reaktanata, maltola i meta- i para-supstituiranih anilina u autoklavu. Odabrani para-supstituirani N-aril-3-hidroksipiridin-4-oni uspješno su sintetizirani i u uvjetima mikrovalne sinteze. Pripravljeni 3-hidroksipiridin-4-oni dodatno su strukturno modificirani uvođenjem lipofilnih podjedinica u njihovu strukturu s naglaskom na adamantilnoj podjedinici. Na piranonski dio molekule 3-hidroksipiridin-4-ona adamantilna podjedinica vezana je esterskim i eterskim tipom veze dok je na meta- i para-položaj arilnog dijela molekule vezana esterskom i amidnom vezom. U disertaciji je opisana i biološka evaluacija pripravljenih spojeva. Ispitivana su antiproliferativna svojstva pripravljenih spojeva te je sustavno istražen odnos strukture i biološke aktivnosti (engl. Structure-Activity Relationship, SAR). Na temelju dobivenih rezultata izdvojeni su najpotentniji spojevi (engl. lead compound) pri čemu je uzet u obzir njihov selektivni antiproliferativni učinak.
Abstract (english)
In this thesis preparation and structural modification of novel N-aryl 3-hydroxypyridin-4-one derivatives is described. Prepared compounds are distinguished by position and structure of substituent on the aryl part of the molecule. Reactions were conducted with heating of aqueous solutions of starting materials, maltol and meta- and para-substituted anilines, in autoclave. Selected para-substituted N-aryl 3-hydroxypyridin-4-ones were successfully prepared in conditions of microwave synthesis. Prepared 3-hydroxypyridin-4-ones were additionally structurally modified by incorporating lipohilic units into pyridinone structure, primarily adamantyl unit. On the pyranone part of the molecule adamantyl unit was introduced by ester and ether bond type and by using ester and amide bond in meta and para position of the aryl part of the molecule. Antiproliferative activity of prepared compounds was examined and structure-activity relationship was systematically researched. On the basis of obtained results lead compounds were singled out whereby selective activity of compounds towards tumor versus normal cell lines was considered.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:798402
Promotion2022
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
ExtentXIV; XVIII, 151 str ; 30 cm
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-04-01
Terms of useLicence In copyright icon
Created on2022-04-06 12:29:56