In this thesis the addition of Grignard reagent on lactones derived from D-ribose was examined with the intention of generating new chiral tertiary alcohols. Although it is known that the addition of two equivalents of a Grignard reagent to an ester will form a tertiary alcohol with two identical substituents, in this thesis the possibility of a sequential addition of two different Grignard reagents in the same reaction was researched. To that end, 5-deoxy-2,3-isopropylidene-D-ribonolactone was synthesized in four steps and used as a substrate for generating chiral tertiary alcohols. Furthermore, synthesis of two functionalized alkyl-bromide derivatives was performed for the preparation of Grignard reagents with others being commercially available. The synthesized ribonolactone was converted into different chiral tertiary alcohols. In the first step of the reaction, allylmagnesium bromide was added and then in the second step the other Grignard reagent was added. With this approach, four chiral tertiary alcohols were generated. The products were isolated and characterized with spectroscopic methods. The obtained results will be of great use in the further development of this methodology with the purpose of introduction of a new chiral tertiary alcohol group to complex molecules. With this in mind, it is a possibility that this method will provide a more efficient and simpler procedure in the synthesis of new active pharmaceutical ingredients.