Međimurje is the northernmost part of Croatia, naturally bordered by the rivers Mura in the north and the Drava in the south, forming the border between Alpine and Pannonian geomorphological units. Forests and agricultural areas predominate in most areas, but the whole region is under pressure from pollutants from various industries. In this paper, the dissolved concentrations of 27 elements in the surface water of the Mura and Drava rivers collected at a total of 14 locations were analyzed in order to obtain an insight into the water status by comparing it with legal norms. The analysis was performed by the technique of high-resolution mass spectrometry with inductively coupled plasma. Although both rivers enter Croatia partially polluted, the results show low concentrations of majority of elements, which coincides with the trend of decreasing pollution. The analysis showed that sulfur in all samples, as well as copper at three locations, was markedly elevated. Given the lack of articles on surface water quality and the limited number of samples in the preparation of this paper, further oversight is needed to understand the specific causes of elevated concentrations.