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undergraduate thesis
Mehanizmi enzimske selektivnosti
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:661190
Keresteš, Gaj
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Keresteš, G. (2022). Mehanizmi enzimske selektivnosti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:661190

Keresteš, Gaj. "Mehanizmi enzimske selektivnosti." Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:661190

Keresteš, Gaj. "Mehanizmi enzimske selektivnosti." Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:661190

Keresteš, G. (2022). 'Mehanizmi enzimske selektivnosti', Undergraduate thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 23 July 2024, https://urn.nsk.hr/urn:nbn:hr:217:661190

Keresteš G. Mehanizmi enzimske selektivnosti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 July 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:661190

G. Keresteš, "Mehanizmi enzimske selektivnosti", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:661190

Metadata
TitleMehanizmi enzimske selektivnosti
Title (english)Mechanisms of enzyme selectivity
AuthorGaj Keresteš
MentorIta Gruić-Sovulj (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Enzimi su biološke makromolekule koje efikasno i selektivno kataliziraju specifične reakcije. Selektivnost enzima se temelji na uspostavljanju specifičnih pozitivnih interakcija s pripadnim supstratima i negativnih interakcija s nepripadnim supstratima u njihovom osnovnom ili prijelaznom stanju. Porodica kimotripsinskih serinskih proteaza obuhvaća enzime koji imaju vrlo različite razine selektivnosti. Za razliku od njih, aminoacil-tRNA-sintetaze (aaRS) su enzimi koji različitim mehanizmima postižu izrazito visoke razine selektivnosti – u sintetskoj reakciji njihova selektivnost doseže fizikalno-kemijske granice, a kasnije se dodatno povećava mehanizmima popravka pogreške. Tijekom evolucije većina enzima prati trend sužavanja supstratne specifičnosti i povećanja selektivnosti, pri čemu selektivnost može biti selektirana izravno ili se razviti kao posljedica optimizacije katalitičke efikasnosti. Evolucija aaRS prati ovaj trend te je aktivno utjecala na razvoj suvremenog genetičkog koda.
Abstract (english)
Enzymes are biological macromolecules that efficiently and selectively catalyze specific reactions. Enzyme selectivity is based on establishing specific positive interactions with cognate substrates and negative interactions with noncognate substrates in their ground or transition states. The chymotrypsin family of serine proteases includes enzymes with very different levels of selectivity. Conversely, aminoacyl-tRNA synthetases (aaRS) are enzymes which, through various mechanisms, achieve extremely high levels of selectivity – their selectivity in the synthetic reaction reaches physicochemical limits and is later additionally increased by proofreading. Throughout evolution, most enzymes followed the trend of narrowing substrate specificity and increasing selectivity. Selectivity can be directly selected for or developed as a consequence of optimizing catalytic efficiency. The evolution of aaRS follows this trend and actively influenced the development of the contemporary genetic code.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:661190
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-04 09:26:18