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undergraduate thesis
Personalizirani pristup liječenju raka
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:900389
Struški, Petra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Struški, P. (2022). Personalizirani pristup liječenju raka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:900389

Struški, Petra. "Personalizirani pristup liječenju raka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:900389

Struški, Petra. "Personalizirani pristup liječenju raka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:900389

Struški, P. (2022). 'Personalizirani pristup liječenju raka', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 18 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:900389

Struški P. Personalizirani pristup liječenju raka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 December 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:900389

P. Struški, "Personalizirani pristup liječenju raka", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:900389

Metadata
TitlePersonalizirani pristup liječenju raka
Title (english)A personalized approach to cancer treatment
AuthorPetra Struški
MentorInga Urlić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Tumori su vrlo komplekse i heterogene bolesti čije liječenje je vrlo zahtjevno. U konvencionalnom pristupu liječenja svi pacijenti s istom vrstom tumora primaju sličnu terapiju. Napretkom istraživanja i tehnologije produbljeno je znanje o tumorima te takav pristup liječenju više nije zadovoljavajuć. Međutim, novootkriveno znanje nije lako prenijeti u kliničku primjenu. Probleme uzrokuje adaptabilnost tumora te velika količina informacija prekompleksnih za interpretaciju. U ovom radu prezentirane su metode istraživanja te personaliziranog tretmana tumora. Sve metode se prvenstveno temelje na biopsiji, metodama molekularnog profiliranja, kulturi stanica te biomarkerima. Iz toga proizlaze modeli ksenografta i organoida te adoptivna stanična terapija i cjepivo protiv raka. Važnost ksenografta i organoida je pružanje što vjernijeg modela tumora ex vivo da bi se determinirala najbolja moguća terapija za pojedinog pacijenta. S druge strane, metode cjepiva i adoptivne stanične terapije omogućuju imunološkom sustavu pacijenta da napada tumor. Rezultati spomenutih metoda su vrlo obećavajući, ali imaju i određene nedostatke kojih moramo biti svjesni. Za dobivanje najboljih rezultata u istraživanju i tretmanu raka trebamo kombinirano koristiti dostupne metode i pažljivo interpretirati rezultate. U svakom slučaju, personalizirani tretman raka je iznimno djelotvoran za pojedine pacijente. Unatoč tome, takav pristup još uvijek nije spreman za primjenu u generalnoj populaciji.
Abstract (english)
Tumors are extremely complex and heterogeneous diseases whose treatment is very demanding. Conventional approach treats all patients with the same type of tumor with similar therapy. Advances in tumor research and new technology made conventional approaches obsolete. However, newly discovered knowledge is not readily transferable to clinical application. Challenges include adaptability of the tumor and the large amount of information too complex to interpret. In this paper, research methods and personalized tumor treatments are introduced. All methods are founded on biopsy, molecular profiling methods, cell culture and biomarkers. From those base methods emerge xenograft and organoid models, as well as adoptive cell therapy and cancer vaccine. Xenografts and organoids provide us with the most accurate tumor model possible ex vivo to determine the best therapy for the patient. On the other hand, cancer vaccines and adoptive cell therapies enable the patient’s immune system to attack the tumor. These methods give promising results, but they come with certain shortcomings. The best results in cancer research and treatment are obtained by utilizing the mix of available methods and carefully interpreting results. In large, personalized cancer treatment is very successful for singular patients. Nevertheless, it still is not ready for application in the general population
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:900389
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-04 12:53:30