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master's thesis
Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:738066
Babić, Mirjana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Babić, M. (2011). Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:738066

Babić, Mirjana. "Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:738066

Babić, Mirjana. "Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:738066

Babić, M. (2011). 'Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:738066

Babić M. Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:738066

M. Babić, "Uloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:738066

Metadata
TitleUloga polimorfizma gena DRD4 i aktivnosti enzima MAO u razvoju ovisnosti o nikotinu
Title (english)The role of DRD4 gene polymorphism and activity of MAO enzyme in development of nicotine addiction
AuthorMirjana Babić
MentorNela Pivac (mentor)
MentorDubravka Hranilović (sumentor)
Committee memberNela Pivac (predsjednik povjerenstva)
Committee memberDubravka Hranilović (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011-12-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Ovisnost o nikotinu izazvana pušenjem nastaje kao produkt socijalnih, okolišnih i genetičkih čimbenika. Geni dopaminergičkog sustava su povezani s pušenjem. Literatura pokazuje povezanost i/ili nepovezanost polimorfizma varijabilnog broja ponavljanja (VNTR) u trećem egzonu gena dopaminskog receptora tipa 4 (DRD4) i pušenja te smanjenu ili nepromijenjenu aktivnost trombocitne monoaminooksidaze tipa B (MAO-B) u pušača. Cilj ovog rada bio je odrediti postoji li u hrvatskoj populaciji povezanost VNTR-a u genu DRD4 te aktivnosti MAO-B s pušenjem. Genotipizirano je 565 ispitanika, a aktivnost MAO-B određena je u 302 ispitanika. Nije uočena značajna razlika u učestalosti dugih i kratkih alela DRD4 između pušača i nepušača. U muških pušača je pronađena snižena aktivnost MAO-B u odnosu na nepušače, dok u ženskih ispitanika nisu pronađene razlike u aktivnosti tog enzima. Rezultati ovog rada nisu potvrdili hipotezu o povezanosti genotipa DRD4 i pušenja, dok je hipoteza o sniženoj aktivnosti MAO-B kod pušača potvrđena za muške, ali ne i za ženske ispitanike zbog premalog uzorka.
Abstract (english)
Nicotine addiction, related to smoking, develops as a product of social, environmental and genetic factors. Dopaminergic system genes are associated with smoking. Literature shows association and/or lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of D4 dopamine receptor gene (DRD4) and smoking, and reduced or unaltered platelet monoamine oxidase type B (MAO-B) activity in smokers. The aim of this study was to determine whether VNTR in DRD4 gene and MAO-B activity are associated with smoking in Croatian population. Genotyping was done in 565 subjects, while MAO-B activity was determined in 302 subjects. There was no significant difference in distribution of the long and short DRD4 alleles between smokers and non-smokers. MAO-B activity was decreased in male smokers compared to male non-smokers, while in female subjects there were no differences in the activity of this enzyme. The results of this study failed to confirm the hypothesis about the association between DRD4 genotype and smoking, while the hypothesis of the reduced platelet MAO-B activity in smokers was confirmed in male, but not in female subjects because of the small sample.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:738066
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-02 12:35:21