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undergraduate thesis
Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:070021
Peček, Laura
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Peček, L. (2022). Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:070021

Peček, Laura. "Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:070021

Peček, Laura. "Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:070021

Peček, L. (2022). 'Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 21 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:070021

Peček L. Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 May 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:070021

L. Peček, "Predacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:070021

Metadata
TitlePredacija bakterije Bdellovibrio bacteriovorus nad patogenim bakterijama čovjeka
Title (english)Bdellovibrio bacteriovorus – bacterial predation of human pathogenic bacteria
AuthorLaura Peček
MentorMartina Šeruga Musić (mentor)
Committee memberMartina Šeruga Musić (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022-09-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Predacija među bakterijama i dalje je prilično slabo istražena u usporedbi s ekvivalentnim životinjskim međuodnosima. No, kako se zbog ubrzanog širenja antimikrobne rezistencije patogenih bakterija čovjeka teži pronalasku alternativnih načina liječenja, posljednjih su godina objavljeni brojni eksperimenti temeljeni na uporabi predatorskih bakterija u tom aspektu. Reprezentativna vrsta, Bdellovibrio bacteriovorus obligatni je monoflagelatni aerobni Gramnegativni predator, prirodno zastupljen u kopnenim i vodenim ekosustavima te ljudskoj crijevnoj mikrobioti. Napada druge Gram-negativne bakterije ulazeći u njihov periplazmatski prostor, gdje nastavlja svoj rast i razvoj u obliku bdeloplasta, a vrlo učinkovito djeluje i protiv bakterija u sastavu biofilmova. Preživljavajući na nutrijentima domadara, predator produžno raste i dijeli se simultano na nekoliko stanica kćeri, koje zatim izlaze iz probavljene stanice plijena i spremne su započeti ciklus predacije iznova. U širok raspon plijena ove vrste ulaze i brojni poznati uzročnici bolesti, primjerice Pseudomonas aeruginosa, Escherichia coli i Acinetobacter baumanii. Budući da višestruko rezistentni patogeni ne razvijaju otpornost prema napadima ovog predatora, razmatra se korištenje sojeva B. bacteriovorus kao „živih antibiotika“.
Abstract (english)
If compared with animal predatory behavior, bacterial predation is studied and understood quite poorly. As multidrug-resistant human bacterial pathogens are evolving and getting stronger rapidly, it is crucial to develop an alternative for classic antibiotic treatments. During the last couple of decades, predatory bacteria are thought to be one of the possible solutions. Among them, the most well-studied species, Bdellovibrio bacteriovorus is an obligate free-swimming Gram-negative aerobic predator preying upon wide range of other Gram-negative bacteria. It is ubiquitous in nature and can also be found within the human gut microbiota. Upon attacking its prey, the predator enters its periplasmic space and forms a protective structure called a bdelloplast. When the prey is exhausted of all of its nutrients, B. bacteriovorus undergoes a simultaneous non-binary division, which is extremely rare amongst bacteria. The multiple progeny are then released and able to encounter new host cells. Its ability to destroy biofilms and a broad prey range that includes many human pathogens make its use as a “living antibiotic” plausible.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:070021
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-07 08:24:25