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master's thesis
Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:943301
Sanemit, Saranyarat
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Sanemit, S. (2022). Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:943301

Sanemit, Saranyarat. "Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:943301

Sanemit, Saranyarat. "Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:943301

Sanemit, S. (2022). 'Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline', Master's thesis, University of Zagreb, Faculty of Science, accessed 17 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:943301

Sanemit S. Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 May 17] Available at: https://urn.nsk.hr/urn:nbn:hr:217:943301

S. Sanemit, "Priprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:943301

Metadata
TitlePriprava i karakterizacija kompleksa nikla(II) s makrozonskim 4’’-derivatom azitromicina izvedenih iz 3-formil-2-hidroksibenzojeve kiseline
Title (english)Synthesis and characterisation of nickel (II) s cooordination compounds macrozone 4"-derivative of azithromycin derived from 3-formyl-2-hydroxybenzoic acid
AuthorSaranyarat Sanemit
MentorPredrag Novak (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberMirta Rubčić (član povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
Committee memberTomislav Jednačak (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Makrolidni antibiotici poput azitromicina imaju antikancerogeno i protuupalno djelovanje te se široko primjenjuju u liječenju infekcija uzrokovanih Gram-pozitivnim i Gram-negativnim bakterijama. S vremenom bakterije postaju otpornije na makrolidne antibiotike pa je potrebno istražiti nove spojeve koji će pokazati veću biološku aktivnost. Makrozoni predstavljaju nove konjugate derivata azitromicina i tiosemikarbazona. Potencijalna su nova klasa makrolidnih antibiotika koji pokazuju biološku aktivnost usporedivu s azitromicinom. Sami tiosemikarbazoni pokazuju dobru antibakterijsku aktivnost, a njihovi kompleksi s prijelaznim metalima pokazuju bolje antibakterijsko djelovanje te njihovim vezanjem očekujemo dodatno poboljšanje biološke aktivnosti. U ovom radu pripravljen je kompleks nikla(II) s makrozonskim 4''-derivatom azitromicina izvedenim iz 3-formilsalicilne kiseline i benzil-tiosemikarbazida. Svi pripravljeni spojevi okarakterizirani su spektroskopijom NMR i infracrvenom spektroskopijom. Idući korak istraživanja uključit će testove biološke aktivnosti in vitro pripravljenih makrozona na susceptibilne i rezistentne sojeve bakterija.
Abstract (english)
Macrolide antibiotics such as azythromycin possess anticancer and antiinflammatory effects and are widely used in the treatment of infections caused by Gram-pozitive and Gram-negative bacteria. Over time, bacteria have developed resistance to macrolide antibiotics, so it is necessary to discover new compounds with better biological activity. Macrozones represent new conjugates of azithromycin and thiosemicarbazone derivatives. They are potentially a new class of macrolide antibiotics that show biological activity comparable to azithromycin. Thiosemicarbazones themselves show good antibacterial effect, but their complexes with transition metals show even better activity. Hence, we expect an additional improvement of their activity by their coupling to azithromycin. Here we report the synthesis of nickel(II) coordination compound of macrozone 4''- azythromycin conjugate derived from 3- formylsalicylic acid and benzyl thiosemicarbazide. The prepared compounds have been characterized by NMR and infrared spectroscopies. The next step will include in vitro biological evaluation against a panel of susceptible and resistant bacteria strains.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:943301
ProjectNumber: IP-2018-01-8098
Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije
Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions
Acronym: Makrozoni/Macrozones
Leader: Predrag Novak
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-12 09:59:07