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undergraduate thesis
Uloga epigenetike u razvoju bolesti na primjeru karcinoma
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:180600
Stanec, Valerija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Stanec, V. (2022). Uloga epigenetike u razvoju bolesti na primjeru karcinoma (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:180600

Stanec, Valerija. "Uloga epigenetike u razvoju bolesti na primjeru karcinoma." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:180600

Stanec, Valerija. "Uloga epigenetike u razvoju bolesti na primjeru karcinoma." Undergraduate thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:180600

Stanec, V. (2022). 'Uloga epigenetike u razvoju bolesti na primjeru karcinoma', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 03 July 2024, https://urn.nsk.hr/urn:nbn:hr:217:180600

Stanec V. Uloga epigenetike u razvoju bolesti na primjeru karcinoma [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 July 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:180600

V. Stanec, "Uloga epigenetike u razvoju bolesti na primjeru karcinoma", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:180600

Metadata
TitleUloga epigenetike u razvoju bolesti na primjeru karcinoma
Title (english)The role of epigenetics in disease development with a focus on cancer
AuthorValerija Stanec
MentorMirjana Pavlica (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Epigenetika je znanost koja proučava nasljedne promjene u funkciji gena uzrokovane promjenom ekspresije i nastale pod utjecajem epigenetskih mehanizama. Epigenetski mehanizmi uključuju metilaciju DNA (hipometilacija, hipermetilacija), histonske modifikacije (acetilacija, metilacija) i nekodirajuće RNA te su reverzibilni. Aberantna regulacija tih mehanizama može uzrokovati pojavu karcinoma, bolesti kod koje dolazi do nekontrolirane proliferacije stanica. Karcinom se razvija posljedično nakupljanju brojnih epigenetskih i genskih promjena. Zahvaljujući reverzibilnosti epigenetskih modifikacija razvijaju se nove vrste lijekova koje bi se koristile uz već dostupne oblike terapija čime se cilja na poboljšanje ishoda liječenja. Kao detaljniji primjer opsega epigenetskih modifikacija koje se mogu javiti prilikom nastanka specifičnog tipa karcinoma opisan je karcinom dojke.
Abstract (english)
Epigenetics is a branch of science focused on studying heritable alterations in genes caused by changes of expression and driven by epigenetic mechanisms. Epigenetic mechanisms include DNA methylation (hypomethylation, hypermethylation), histone modifications (acetylation, methylation) and non-coding RNAs all of which are reversible modifications. Aberrant regulation of these mechanisms can cause cancer occurrence. Cancer is a disease characterized by uncontrolled cell proliferation and caused by an accumulation of epigenetic and genetic faults. New kinds of potential therapies revolving around the reversal of epigenetic modifications are investigated and are hoped to be used alongside existing therapies to better treatment outcome. For a more detailed look into the extent to which epigenetic modifications occur in a cancer, an example is given describing the breast cancer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:180600
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-13 11:33:29