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master's thesis
Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:152000
Košić, Kristina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Košić, K. (2021). Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:152000

Košić, Kristina. "Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:152000

Košić, Kristina. "Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:152000

Košić, K. (2021). 'Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora', Master's thesis, University of Zagreb, Faculty of Science, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:152000

Košić K. Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:152000

K. Košić, "Utjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:152000

Metadata
TitleUtjecaj akutne neonatalne hipoksije na razinu katekolamina u moždanom deblu mladih štakora
Title (english)Effect of acute neonatal hypoxia on the brainstem catecholamine levels in young rats
AuthorKristina Košić
MentorDubravka Hranilović (mentor)
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
Committee memberSara Essert (član povjerenstva)
Committee memberSofia Ana Blažević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2021-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Fetalna hipoksija je stanje koje karakterizira smanjena koncentracija kisika važnog za normalnu fiziološku funkciju tkiva te normalan razvoj fetusa. Posljedice smanjene koncentracije kisika očituju se kroz razne neurološke poremećaje kao što su motoričke smetnje, autonomna disfunkcija, epilepsija, poremećaj pamćenja i pažnje. S obzirom na ulogu katekolamina u regulaciji adaptivnih ponašanja svojstvenih svim sisavcima, dopaminergički i noradrenergički neuronski krugovi mogli bi predstavljati mehanizam kojim hipoksija utječe na spomenute neurološke poremećaje. Cilj ovog rada jest analizirati utjecaj neonatalne izloženosti štakora kratkotrajnoj akutnoj hipoksiji na koncentraciju katekolamina u moždanom deblu u adolescentnoj dobi. Koncentracija katekolamina je određena pomoću komercijalnog kompleta enzimskog imunotesta na čvrstoj fazi (engl. Enzyme-Linked Immunosorbent Assay, ELISA). Životinje iz hipoksične skupine imale su značajno povišenu koncentraciju dopamina u moždanom deblu, dok se koncentracija noradrenalina nije promijenila u odnosu na kontrolnu skupinu. Rezultati istraživanja pokazuju da neonatalna izloženost blagoj prolaznoj hipoksiji dugoročno narušava homeostazu dopamina.
Abstract (english)
Fetal hypoxia is a condition characterized by a reduced concentration of oxygen essential for normal physiological tissue function and normal fetal development. The consequences of the decreased oxygen supply are manifested through various neurological disorders such as motor disorders, autonomic dysfunction, epilepsy, memory, and attention disorders. Knowing the role of catecholamines in the inherited adaptive behavioural regulations of all mammals, dopaminergic and noradrenergic neuronal pathways could represent the mechanism by which hypoxia affects the aforementioned neurological disorders. This study aimed to analyze the effect of neonatal exposure to short-term acute hypoxia on the brainstem catecholamine levels in young rats. Catecholamine concentration has been determined using a commercial Enzyme-Linked Immunosorbent Assay, ELISA kit. Animals in the hypoxic group had significantly increased concentrations of the brainstem dopamine, while the concentration of norepinephrine did not change compared to the control group. The results of the research show that neonatal exposure to mild transient hypoxia leads to a long-lasting disruption of dopamine homeostasis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:152000
ProjectNumber: IP-2019-04-3182
Title: Moždani izvanstanični matriks u razvitku i perinatalnoj hipoksiji
Title: Brain extracellular matrix in development and in perinatal hypoxia
Acronym: BRAINECM
Leader: Nataša Jovanov Milošević
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
ProjectNumber: KK.01.1.1.01.0007
Title: Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Leader: Miloš Judaš
Jurisdiction: Croatia
Funder: ERDF
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-28
Terms of useLicence In copyright icon
Created on2022-10-17 09:29:09