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master's thesis
Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:444136
Perković, Ivana
University of Zagreb
Faculty of Science
Department of Physics

Institutional repository: Repository of the Faculty of Science

Cite this document

Perković, I. (2022). Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:444136

Perković, Ivana. "Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:444136

Perković, Ivana. "Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:444136

Perković, I. (2022). 'Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica', Master's thesis, University of Zagreb, Faculty of Science, accessed 19 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:444136

Perković I. Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 May 19] Available at: https://urn.nsk.hr/urn:nbn:hr:217:444136

I. Perković, "Proučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:444136

Metadata
TitleProučavanje sila odgovornih za pozicioniranje kromosoma tokom diobe ljudskih stanica
Title (english)Study of the forces responsible for the positioning of chromosomes during human cell division
AuthorIvana Perković
MentorNenad Pavin (mentor)
Committee memberNenad Pavin (predsjednik povjerenstva)
Committee memberMatko Glunčić (član povjerenstva)
Committee memberMaja Planinić (član povjerenstva)
Committee memberTomislav Bokulić (član povjerenstva)
Committee memberKatarina Jeličić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Physics)
Zagreb
Defense date and country2022-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
Stanična dioba je esencijalni proces kontinuiteta života. Tokom stanične diobe formira se diobeno vreteno koje je odgovorno za ispravnu podjelu genetskog materijala na novonastale stanice kćeri. Diobeno vreteno kao aktivan element mitoze sadrži mikrotubule, motorne proteine te različite dodatne proteine čija je uloga ključna u samom formiranju diobenog vretena kao i pravilnom pozicioniranju kromosoma koje rezultira uspješnom podjelom genetskog materijala. Spomenuti elementi generiraju sile, koje će se koristiti za opisivanje mehanizma poravnanja kromosoma na ekvatorijalnoj ravnini diobenog vretena. U ovom diplomskom radu proučavan je model koji razmatra sile interakcije kinetohornih i premosnih mikrotubula, gdje su premosni mikrotubuli definirani kao mikrotubuli koji se protežu između sestrinskih kinetohora. Dodatne sile koje su proučavane uključuju sile generirane od strane motornih proteina i pasivnih vezivnih proteina na područjima antiparalelnih, odnosno paralelnih preklapanja premosnih i kinetohornih vlakana, interakciju kinetohora s mikrotubulima te ravnotežne sile između sestrinskih kinetohora.
Abstract (english)
Cell division is an essential process of life continuity. During cell division, a mitotic spindle is formed, which is responsible for the correct division of genetic material into newly formed daughter cells. The spindle, as an active element of mitosis, contains microtubules, motor proteins and various additional proteins whose role is crucial in the formation of the spindle itself, as well as in the proper positioning of chromosomes, which results in the successful division of genetic material. The mentioned elements generate forces, which will be used to describe the mechanism of chromosome alignment on the equatorial plane of the mitotic spindle. In this thesis we use a model that considers the interaction forces of kinetochore and bridging microtubules, where bridging microtubules are defined as microtubules that extend between sister kinetochores. Additional forces that were studied include forces generated by motor proteins and passive crosslinkers at the areas of antiparallel and parallel overlaps of bridging and kinetochore fibers, kinetochore interaction with microtubules, and equilibrium forces between sister kinetochores.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:444136
Study programmeTitle: Physics; specializations in: Education
Course: Education
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra edukacije fizike (magistar/magistra edukacije fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-19 10:37:53