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master's thesis
Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:123414
Milićević, Lucija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Milićević, L. (2022). Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:123414

Milićević, Lucija. "Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:123414

Milićević, Lucija. "Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:123414

Milićević, L. (2022). 'Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:123414

Milićević L. Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:123414

L. Milićević, "Povezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:123414

Metadata
TitlePovezanost polimorfizama gena nasljedne trombofilije s pojavom spontanog pobačaja u žena
Title (english)The association of polymorphisms of hereditary trombophilia genes with appearance of spontaneous abortion in women
AuthorLucija Milićević
MentorIvanka Mikulić (mentor)
MentorNada Oršolić (komentor)
Committee memberNada Oršolić (predsjednik povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberRenata Šoštarić (član povjerenstva)
Committee memberPerica Mustafić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Spontani pobačaj je neizazvana smrt embrija ili fetusa ili izbacivanje produkta začeća prije 20. tjedna trudnoće. Najčešći čimbenici spontanih pobačaja su kromosomske aberacije, endokrinološke, infektivne i imunološke bolesti, anatomske abnormalnosti maternice ili hiperkoagulabilna stanja. Postoji povezanost između nasljedne i stečene trombofilije i brojnih komplikacija u trudnoći, uključujući intrauterini zastoj rasta ploda, spontani pobačaj, preeklampsiju i abrupciju posteljice. Cilj ovog rada bio je istražiti povezanost genskih polimorfizama faktora V Leiden FVQ506, faktora II Protrombin G20210A, metilentetrahidrofolatreduktaza (MTHFR) C677T, inhibitora aktivatora plazminogena (PAI-1-) -5675 4G/5G i faktora FXIII G103T kod žena koje su imale spontani pobačaj te ih usporediti s genima žena koje nisu imale spontani pobačaj. Također uspoređene su kombinirane alelne varijante ispitivanih genskih polimorfizama između ispitivane i kontrolne skupine. Prema dobivenim rezultatima nije moguće tvrditi da prisutnost nekog od haplotipova značajno povećava izglede, odnosno vjerojatnost za spontani pobačaj.
Abstract (english)
Spontaneous abortion is the unprovoked death of an embryo or fetus or the expulsion of the product of conception before the 20th week of pregnancy. The most common causes of spontaneous abortions are chromosomal aberrations, endocrinological, infections and immunological diseases, anatomical abnormalities of the uterus or hypercoagulable conditions. There is connection between hereditary and acquired thrombophilia and numerous preeclampsia and placental abruption. The aim of this work was to investigate the association of gene polymorphisms of factor-V Leiden FVQ506, factor II Protrombin G20210A, methylentetrahydrofolate reductase (MTHFR) C677T, plasminogen activator inhibitor (PAI-1-) -5675 4G/5G and factor FXIII G103T in women who had spontaneous miscarriage and compare them with alleles of the same genes of women who did not have a miscarriage. The combined allelic variants of the tested gene polymorphisms between the tested and control groups were compared as well. According to the obtained results, it is not possible to claim that the presence of any haplotypes significantly increase the probability of spontaneous abortion.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:123414
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-21 10:16:15