prikaz prve stranice dokumenta Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre
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master's thesis
Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:875881
Mikloš, Morana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mikloš, M. (2011). Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:875881

Mikloš, Morana. "Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:875881

Mikloš, Morana. "Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:875881

Mikloš, M. (2011). 'Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre', Master's thesis, University of Zagreb, Faculty of Science, accessed 05 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:875881

Mikloš M. Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2024 May 05] Available at: https://urn.nsk.hr/urn:nbn:hr:217:875881

M. Mikloš, "Povezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:875881

Metadata
TitlePovezanost alela mikrosatelita unutar regije gena za čimbenik nekroze tumora s akutnim odbacivanjem transplantata jetre
Title (english)The association of tumor necrosis factor microsatellite polymorphisms and acute liver graft rejection
AuthorMorana Mikloš
MentorZorana Grubić (mentor)
Committee memberZorana Grubić (predsjednik povjerenstva)
Committee memberŽeljka Vidaković-Cifrek (član povjerenstva)
Committee memberDubravka Hranilović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011-06-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U ovom radu istražena je raznolikost alela lokusa HLA-A, -B i -DRB1 te alela mikrosatelita TNFa, TNFb i TNFd u skupini od 35 parova davatelj-primatelj u programu nesrodne transplantacije jetre, od kojih je 29 bolesnika imalo epizode akutnog odbacivanja, a šest bolesnika nije. Dobiveni rezultati uspoređeni su s kontrolnom skupinom koja je uključivala 200 zdravih nesrodnih ispitanika. Aleli HLA određeni su molekularnom metodom (PCR-SSP, Polymerase Chain Reaction-Sequence Specific Primers), a aleli mikrosatelita TNF metodom PCR-STR (Short Tandem Repeats). Nije uočena statistički značajna razlika u zastupljenosti alela HLA između bolesničke i kontrolne skupine. Utvrđena je statistički značajno povećana zastupljenost alela TNFa5 među bolesnicima u odnosu na kontrolu. Nije uočena razlika u broju nepodudarnosti HLA i TNF između bolesnika s akutnim i bez akutnog odbacivanja jetre.
Abstract (english)
The polymorphism of HLA-A, -B and -DRB1 loci, and TNFa, TNFb and TNFd microsatellites was investigated in this study among 35 donor-recipient pairs in unrelated liver transplantation program. Episodes of acute rejection were observed for 29 patients, while six patients did not demonstrate acute rejection. Obtained results were compared with results of control group (200 healthy, unrelated subjects). HLA specificities were determined using the PCR-SSP (Polymerase Chain Reaction-Sequence Specific Primers) molecular method, while the determination of alleles at TNF microsatellites was performed by PCR-STR (Short Tandem Repeats) method. No statistically significant difference in the distribution of HLA specificities between controls and patients was observed. A statistically significant increase of TNFa5 allele's frequency was shown among patients when compared to controls. No difference in number of HLA and TNF mismatches between patients with and patients without acute liver rejection was observed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:875881
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-03 09:34:06