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master's thesis
Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:643528
Mohila, Sanja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mohila, S. (2011). Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:643528

Mohila, Sanja. "Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:643528

Mohila, Sanja. "Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:643528

Mohila, S. (2011). 'Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide', Master's thesis, University of Zagreb, Faculty of Science, accessed 28 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:643528

Mohila S. Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2025 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:643528

S. Mohila, "Zastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:643528

Metadata
TitleZastupljenost serotipova bakterije Streptococcus pneumoniae među sojevima rezistentnim na makrolide
Title (english)Distribution of Streptococcus pneumoniae serotypes among macrolide-resistant strains
AuthorSanja Mohila
MentorJasmina Vraneš (mentor)
Committee memberAna Galov (predsjednik povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberJasna Hrenović (član povjerenstva)
Committee memberJasmina Vraneš (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011-01-31, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Streptococcus pneumoniae često kolonizira ždrijelo djece, a kad je imunost domaćina nedostatna može se rasprostranjivati dalje i izazvati upalu srednjeg uha, pneumoniju ili čak sepsu ili meningitis. Rezistencija na antibiotike S. pneumoniae predstavlja važan javno-zdravstveni izazov u mnogim zemljama. U ovom istraživanju prikupljeno je ukupno 165 izolata S. pneumoniae rezistentnih na makrolide u djece mlađe od 16 godina u različitim regijama Hrvatske (zagrebačko, riječko, osječko i varaždinsko... More područje). Svrha istraživanja bila je usporedba zastupljenosti pojedinih serotipova među rezistentnim sojevima S. pneumoniae. Najčešći serotipovi su bili 19A i 19F. Drugi serotipovi (1, 3, 5, 8, 6A, 6B, 6C, 9, 10, 11, 14, 15, 17 i 18C) detektirani su s niskom zastupljenošću. Makrolidna rezistencija kod sojeva prikupljenih u Osijeku i Varaždinu bila je udružena sa serotipom 19A, dok je makrolidna rezistencija sojeva prikupljenih u Rijeci i Zagrebu bila udružena sa serotipom 19F (p<0,01). Pokrivenost serotipova sedam-valentnim konjugiranim cjepivom je niska u osječkoj i varaždinskoj regiji te je opaženo pojavljivanje serotipa 19A koji nije uključen u sedam-valentno konjugirano cjepivo među sojevima rezistentnim na makrolide. Less
Abstract (english)
Streptococcus pneumoniae commonly colonises the nasopharynx of children, and when the host's immunity is impaired it can spread and cause otitis media, sinusitis, pneumonia or even sepsis or meningitis. Antibiotic resistance within Streptococcus pneumoniae represents a major healthcare challenge in many countries. In this study, a total of 165 macrolide-resistant isolates, were obtained from children under 16 years of age in different regions of Croatia (Zagreb, Rijeka, Osijek and Varazdin... More Regions). The aim of the study was to compare the distribution of the serotypes among resistant strains. The most common serotypes were 19A and 19F. Other serotypes (1, 3, 5, 8, 6A, 6B, 6C, 9, 10, 11, 14, 15, 17 and 18C) were detected with a low frequency.The macrolide-resistance in strains collected in Osijek and Varazdin regions was associated with serotype 19A, and the resistance in strains collected in Rijeka and Zagreb regions was associated with serotype 19F (p<0.01). Serotype coverage for the 7-valent conjugate vaccine in Osijek and Varazdin region is low and emergence of a macrolide-resistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine is detected. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:643528
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-03 09:37:15
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