prikaz prve stranice dokumenta The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides
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doctoral thesis
The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:985093
Stolar, Tomislav
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Stolar, T. (2022). The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:985093

Stolar, Tomislav. "The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:985093

Stolar, Tomislav. "The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:985093

Stolar, T. (2022). 'The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 07 October 2024, https://urn.nsk.hr/urn:nbn:hr:217:985093

Stolar T. The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 October 07] Available at: https://urn.nsk.hr/urn:nbn:hr:217:985093

T. Stolar, "The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:985093

Metadata
TitleThe role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides
Title (croatian)Uloga reaktivnosti u čvrstom stanju u prebiotičkom odabiru nukleobaza i stvaranju peptida
AuthorTomislav Stolar
MentorKrunoslav Užarević (mentor)
Committee memberMirta Rubčić (predsjednik povjerenstva)
Committee memberSanda Rončević (član povjerenstva)
Committee memberOliver Trapp https://orcid.org/0000-0002-3594-5181 (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-08-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Within this thesis, solid-state reaction medium and mechanochemical methodologies were explored to unveil weather nucleobases can self-assemble and amino acids can oligomerize under these conditions. X-ray diffraction and differential scanning calorimetry analysis showed that 2,6-diaminopurine (D) selectively self-assembles with uracil (U) and thymine (T), while adenine (A) self-assembles with hypoxanthine (H). Crystal structures of D-U cocrystal hydrate, D-T cocrystal hydrate, D-T cocrystal anhydrate, A-H cocrystal hydrate, and A-H cocrystal anhydrate were determined from powder X-ray diffraction and single-crystal X-ray diffraction data. Ion-pairing high performance liquid chromatography and mass spectrometry analysis showed that glycine and alanine undergo oligomerization by mechanical activation. Based on the results, it can be concluded that minerals as additives, time, mechanical loading, and temperature are all important parameters for the mechanochemical prebiotic peptide synthesis. In summary, solid-state reactivity of nucleobases and amino acids might have been an important factor in their prebiotic chemical evolution.
Abstract (croatian)
U ovoj doktorskoj disertaciji koristili smo čvrsto stanje kao reakcijski medij i mehanokemijske metodologije da bismo istražili dolazi li do prepoznavanja nukleobaza i oligomerizacije aminokiselina u tim uvjetima. Analiza difrakcijom rentgenskog zračenja i diferencijalnom pretražnom kalorimetrijom pokazala je selektivno molekulsko prepoznavanje 2,6-diaminopurina (D) s uracilom (U) i timinom (T), kao i adenina (A) s hipoksantinom (H). Riješene su kristalne strukture D-U kokristalnog hidrata, D-T kokristalnog hidrata, D-T kokristalnog anhidrata, A-H kokristalnog hidrata te A-H kokristalnog anhidrata iz podataka difrakcije rentgenskog zračenja. Analiza tekućinskom kromatografijom visoke djelotvornosti i spektrometrijom mase pokazala je da glicin i alanin oligomeriziraju u peptide uslijed mehanokemijske aktivacije. Rezultati su pokazali da su minerali kao aditivi, vrijeme, prenošenje mehaničke energije, i temperatura ključni parametri za mehanokemijsku prebiotičku sintezu peptida. Zaključeno je da je reaktivnost nukleobaza i aminokiselina u čvrstom stanju mogla biti važan faktor u njihovoj prebiotičkoj kemijskoj evoluciji.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:217:985093
Promotion2022
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent160 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-08-26
Terms of useLicence In copyright icon
Created on2022-11-03 14:33:43