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master's thesis
Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:112448
Gašpar, Martina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Gašpar, M. (2016). Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2 (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:112448

Gašpar, Martina. "Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:112448

Gašpar, Martina. "Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:112448

Gašpar, M. (2016). 'Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:112448

Gašpar M. Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:112448

M. Gašpar, "Učestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:112448

Metadata
TitleUčestalost ketoacidoze u bolesnika sa šećernom bolešću tipa 2
Title (english)Incidence of diabetic ketoacidosis in patients with type 2 diabetes
AuthorMartina Gašpar
MentorDario Rahelić (mentor)
MentorDomagoj Đikić (mentor)
Committee memberDomagoj Đikić (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
Committee memberJasna Hrenović (član povjerenstva)
Committee memberPetar Kružić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016-02-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Dijabetička ketoacidoza je jedna od najopasnijih akutnih komplikacija šećerne bolesti te može rezultirati visokom stopom smrtnosti ako nije odgovarajuće ili na vrijeme liječena. Glavni uzrok ovog stanja su nedostatak inzulina i povišene razine protu-regulatornih hormona (glukagona, hormona rasta, katekolamina i kortizola). Do nedavno se smatralo da je ketoacidoza gotovo isključivo vezana uz tip 1 šećerne bolesti, ali sve više istraživanja prikazuju njenu prisutnost u tipu 2 šećerne bolesti. Cilj ovog istraživanja je bio odrediti učestalost i moguće razloge nastanka ketoacidoze u bolesnika sa šećernom bolešću tipa 2. Istraživanje je uključivalo pretraživanje baze podataka Kliničke bolnice Dubrava u razdoblju od 1. srpnja 2010. godine do 1. srpnja 2015. godine te analizu podataka o kliničkom profilu pacijenata. Kod novodijagnosticiranih bolesnika odredila se koncentracija glukoze u krvi, acidobazni status te vrijednosti glikiranog hemoglobina. Od 72 pacijenta, njih 27 (37.2%) imalo je tip 1 šećerne bolesti i 45 (62.5%) tip 2 šećerne bolesti. U skupini pacijenata sa šećernom bolešću tipa 1, osam pacijenata (27.5%) su imala epizodu ketoacidoze kao prvi znak šećerne bolesti, dok je u skupini bolesnika sa šećernom bolešću tipa 2, trinaest pacijenata (28.8%) imalo je dijabetičku ketoacidozu kao prvi znak šećerne bolesti. Nepridržavanje terapije i infekcije bili su najčešći uzroci ketoacidoze.
Abstract (english)
Diabetic ketoacidosis is one of the most dangerous acute complications of diabetes, responsible for significant mortality if not treated properly and on time. The main features of this condition are insulin deficiency and increased levels of counter-regulatory hormones (glucagon, growth hormone, catecholamines and cortisol). Until recently it was thought that ketoacidosis is present only in type 1 diabetes, but more studies reported its presence in type 2 diabetes. Aim of this study was to establish the frequency and precipitating factors for the occurrence of diabetic ketoacidosis in patients with type 2 diabetes. The research involved searching data bases in the period from July 1st 2010 until July 1st 2015 and clinical profile of patients were analyzed. In newly diagnosed patients, concentration of blood glucose, acid-base status and the values of glycated hemoglobin were determined. Out of 72 patients, 27 (37.2%) had type 1 and 45 (62.5%) had type 2 diabetes. Among patients with type 1 diabetes, 8 (27.5%) patients had an episode of ketoacidosis as the initial case of diabetes, whereas among patients with type 2, 13 (28.8%) patients had mentioned complication as a first sign of disease. Non-compliance to treatment and infection were the most common causes of ketoacidosis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:112448
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-03 09:55:35