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doctoral thesis
PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:550775
Babić, Slaven
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Babić, S. (2022). PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:550775

Babić, Slaven. "PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:550775

Babić, Slaven. "PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:550775

Babić, S. (2022). 'PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:550775

Babić S. PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 December 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:550775

S. Babić, "PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:550775

Metadata
TitlePREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA
Title (english)PREVENTION OF CELL DEATH DUE TO THERMAL OSTEONECROSIS BY USING NEWLY DESIGNED MEDICAL DRILLS
AuthorSlaven Babić
MentorAljoša Matejčić (mentor)
Committee memberInga Urlić (predsjednik povjerenstva)
Committee memberBiljana Balen (član povjerenstva)
Committee memberIvan Dobrić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Termička osteonekroza je oštećenje kosti koje nastaje tijekom medicinskih intervencija u ortopediji i traumatologiji. Pri bušenju kosti dolazi do porasta temperature uz mjesto bušenja. Kad porast temperature i vrijeme izlaganja povišenoj temperaturi premašuju kritične razine, nastaju nepovratna oštećenja stanica. Da bi se termičko oštećenje kosti preveniralo, mjesto bušenja potrebno je hladiti ili rabiti drukčiji dizajn svrdala od dosadašnjih, koja manje zagrijavaju okolno tkivo. U tu svrhu dizajnirana su dvostupnjevana svrdla s više kombinacija užeg i šireg stupnja te je uspoređena razlika porasta temperature sa standardnim svrdlima bušenjem na umjetnom materijalu. Bušenje na kostima izvedeno je odabranim kombinacijama svrdala s najvećim potencijalom smanjenja porasta temperature, a uzorci koštanog tkiva s ruba provrta kvantitativno su histološki analizirani. Ovo istraživanje pokazalo je da se kod dvostupnjevanih svrdala razvijaju manje temperaturu okolne kosti od standardnih svrdala te da je oštećenje stanica proporcionalno porastu temperature. Dvostupnjevana svrdla primjenjiva su u ortopediji i traumatologiji
Abstract (english)
Thermal osteonecrosis is bone damage that occurs during medical interventions in orthopaedics and traumatology. The temperature in the procedures of drilling bones rises near the drilling site. When the temperature rises and the time of exposure to elevated temperature exceeds critical levels, irreversible cell damage occurs. In order to prevent thermal damage to the bone, it is necessary to cool the drilling site or use a different design of drills, which causes less temperatures and less damage to the surrounding tissue. For this purpose, two-stage drills with several combinations of narrower and wider stages were designed, and the difference in temperature rise was compared with standard drill bits, by drilling on artificial material. Drilling on bone tissue samples was performed with selected drill combinations which proved to have the greatest potential to reduce the temperature rise. These samples were quantitatively histologically analyzed. This study showed that two-stage drills develop a lower bone temperature than standard drills and that cell damage is proportional to temperature rise. Twostage drills are applicable in orthopaedic surgery.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:550775
Promotion2022
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-09-20
Terms of useLicence In copyright icon
Created on2022-11-14 11:36:15