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doctoral thesis
PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:323647
Koska, Sara
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Koska, S. (2022). PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:323647

Koska, Sara. "PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:323647

Koska, Sara. "PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:323647

Koska, S. (2022). 'PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:323647

Koska S. PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:323647

S. Koska, "PHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:323647

Metadata
TitlePHYLOGENY-ONTOGENY CORRESPONDENCE IN Bacillus subtilis BIOFILMS
Title (croatian)SUODNOS FILOGENIJE I ONTOGENIJE BIOFILMOVA BAKTERIJE Bacillus subtilis
AuthorSara Koska
MentorTomislav Domazet-Lošo (mentor)
Committee memberDamjan Franjević (predsjednik povjerenstva)
Committee memberJasna Hrenović (član povjerenstva)
Committee memberIvan Mijaković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2022-05-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Genetics, Evolution and Phylogenetics
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Links between ontogeny and phylogeny in animals have been discussed for more than two centuries. With the uprising of molecular biology and bioinformatics, several studies have revealed the presence of the phylogeny-ontogeny correlation on molecular level in developmental transcriptomes of eukaryotic clades with complex multicellularity. These findings open a possibility to test the phylogeny-ontogeny correlation in more basal organisms, with more obscure development and multicellularity characteristics. Using time-resolved transcriptome and proteome profiles, this study showed that Bacillus subtilis biofilm ontogeny correlates with the evolutionary measures through recapitulation pattern, in a way that evolutionary younger and more diverged genes were increasingly expressed towards the later timepoints of the biofilm growth. Molecular and morphological signatures also revealed that biofilm growth is highly regulated and organized into discrete ontogenetic stages. Together, this suggests that the biofilm formation in Bacillus subtilis is a true developmental process comparable to organismal development in animals, plants and fungi
Abstract (croatian)
Korelacija između filogenije i ontogenije životinja je predmet rasprave među znanstvenicima od početka 19. stoljeća. Razvojem molekularne biologije i bioinformatike te analizama transkriptoma razvojnih stadija, uočena je prisutnost korelacije filogenije i ontogenije na molekularnoj razini u eukariotskim evolucijskim granama sa složenom višestaničnosti. Ova saznanja potaknula su nas da testiramo korelaciju filogenije i ontogenije u bazalnim organizmima s nejasnim razvojnim i višestaničnim karakteristikama. Analizom transkriptomskih i proteomskih podataka, pokazali smo da ontogenija Bacillus subtilis biofilmova korelira s evolucijskim mjerama u obliku rekapitulacijskog profila, odnosno evolucijski mlađi i divergentniji geni su sve više eksprimirani prema kasnijim stadijima rasta biofilma. Dodatne molekularne analize pokazale su da je rast biofilma reguliran i organiziran u jasno odvojene stadije ontogenije. Zaključno, rezultati pokazuju da je rast Bacillus subtilis biofilmova istinski razvojni proces usporediv s razvojem životinja, biljaka i gljiva.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:217:323647
Promotion2022
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-11-22 12:08:30