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master's thesis
Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:805592
Prkić, Ivana
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Prkić, I. (2022). Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:805592

Prkić, Ivana. "Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:805592

Prkić, Ivana. "Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina." Master's thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:805592

Prkić, I. (2022). 'Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina', Master's thesis, University of Zagreb, Faculty of Science, accessed 05 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:805592

Prkić I. Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2025 January 05] Available at: https://urn.nsk.hr/urn:nbn:hr:217:805592

I. Prkić, "Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:805592

Metadata
TitleForsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina
Title (english)Forced degradation of loratadine and loratadine/cyclodextrin inclusion complexes
AuthorIvana Prkić
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberDavor Kovačević (član povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-11-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Loratadin je antihistaminik, koji prema biofarmaceutskom klasifikacijskom sustavu spada u skupinu lijekova slabe topljivosti. Međutim njegova topljivost, ali i stabilnost može se poboljšati stvaranjem inkluzijskih kompleksa s ciklodekstrinima. Stabilnost lijekova od velike je važnosti u farmaceutskoj industriji jer utječe na njihovu sigurnost i učinkovitost. Forsiranom razgradnjom dobivaju se informacije o stabilnosti lijeka i razgradnim produktima koji nastaju. U ovom radu istražen je utjecaj β-ciklodekstrina na stabilnost loratadina. Postotak razgradnje loratadina određen je tekućinskom kromatografijom ultra visoke djelotvornosti. Uzorci s uočenim potencijalnim razgradnim produktima analizirani su vezanim sustavom tekućinske kromatografije i spektrometrije masa visokog razlučivanja. Na temelju MS i MS/MS spektara predložene su strukture razgradnih produkata.
Abstract (english)
Loratadine is antihistamine that is categorized in Biopharmaceutics Classification System as a poorly soluble drug. However, its solubility and stability can be improved by formation of inclusion complexes with cyclodextrins. The stability of drugs is of great importance in the pharmaceutical industry because it affects their safety and efficacy. Forced degradation provides information on stability of drugs and resulting degradation products. In this work effect of β-cyclodextrin on stability of loratadine was studied. Ultra-high performance liquid chromatography was used to determine the percentage of degradation in each sample. Liquid chromatography coupled to high resolution mass spectrometer was used on selected samples. Structures of degradants and fragmentation pathways were proposed based on obtained results.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:805592
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-11-17
Terms of useLicence In copyright icon
Created on2022-12-01 15:02:57