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doctoral thesis
Utjecaj najčešćih onečišćenja na kristalne forme entakapona
Zagreb: University of Zagreb, Faculty of Science, 2022. urn:nbn:hr:217:413091
Vušak, Vitomir
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Vušak, V. (2022). Utjecaj najčešćih onečišćenja na kristalne forme entakapona (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:413091

Vušak, Vitomir. "Utjecaj najčešćih onečišćenja na kristalne forme entakapona." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:413091

Vušak, Vitomir. "Utjecaj najčešćih onečišćenja na kristalne forme entakapona." Doctoral thesis, University of Zagreb, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:217:413091

Vušak, V. (2022). 'Utjecaj najčešćih onečišćenja na kristalne forme entakapona', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 14 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:413091

Vušak V. Utjecaj najčešćih onečišćenja na kristalne forme entakapona [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2022 [cited 2025 January 14] Available at: https://urn.nsk.hr/urn:nbn:hr:217:413091

V. Vušak, "Utjecaj najčešćih onečišćenja na kristalne forme entakapona", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:217:413091

Metadata
TitleUtjecaj najčešćih onečišćenja na kristalne forme entakapona
Title (english)Influence of the most common impurities on the crystal forms of entacapone
AuthorVitomir Vušak
MentorErnest Meštrović (mentor)
Committee memberVesna Petrović-Peroković (predsjednik povjerenstva)
Committee memberAleksandra Sander (član povjerenstva)
Committee memberIvan Halasz (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2022-05-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Sustavno istraživanje polimorfije organskih spojeva, a posebno djelatnih tvari, u fokusu je znanstvenih istraživanja više od 50 godina. Izuzetno su dobro istraženi fizikalni parametri koji utječu i dovode do nastanka polimorfnih formi, te je uspostavljena metodologija njihove identifikacije i karakterizacije. S druge strane, malobrojna su sustavna istraživanja kojima se nastoji spoznati u kojoj mjeri određena onečišćenja imaju utjecaj na nastanak i varijabilnost polimorfnih formi. U nakani da se potvrdi hipoteza da određena onečišćenja ili međuprodukti koji nastaju prilikom priprave djelatnih tvari mogu imati utjecaj na varijabilnost polimorfije, kao modelni spoj odabran je entakapon. Priređena je biblioteka od 11 strukturno sličnih onečišćenja te većina u literaturi opisanih polimorfnih formi entakapona. Nakon toga je provedeno istraživanje u kojem je korištenjem metoda cijepljenja i obogaćenog uzorka ispitan utjecaj vrste i strukture onečišćenja na varijabilnost polimorfije. Ustanovljeno je da je taj utjecaj veći što su spojevi sličnije građe. Na temelju dobivenih podataka potvrđena je osnovna hipoteza ovog rada.
Abstract (english)
Systematic research of polymorphism of organic compounds and especially active substances, has been the focus of scientific research for more than 50 years. The physical parameters that lead to formation of certain polymorphic forms have been well researched and the methodology of identification and characterization has been established. On the other hand, there is very little systematic approach to determine the extent and impact of certain contaminants on the formation and variability of polymorphic forms. In order to confirm the hypothesis that certain impurities or intermediates used in the preparation may affect the variability of polymorphism, entacapone was selected as model compound. A library of 11 structurally related compounds and polymorphic forms of entacapone described in the literature were prepared. A study in which the influence of impurities on the variability of polymorphism was examined using seed or spike methods. This effect was found to be greater with structuraly similar compounds. Based on collected data, the basic hypothesis of this thesis was confirmed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:413091
Promotion2023
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent187 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-01-31 15:05:35