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master's thesis
Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece
Zagreb: University of Zagreb, Faculty of Science, 2010. urn:nbn:hr:217:008577
Čižmek, Ines
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Čižmek, I. (2010). Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:008577

Čižmek, Ines. "Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece." Master's thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:008577

Čižmek, Ines. "Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece." Master's thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:008577

Čižmek, I. (2010). 'Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece', Master's thesis, University of Zagreb, Faculty of Science, accessed 12 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:008577

Čižmek I. Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2010 [cited 2025 March 12] Available at: https://urn.nsk.hr/urn:nbn:hr:217:008577

I. Čižmek, "Usporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2010. Available at: https://urn.nsk.hr/urn:nbn:hr:217:008577

Metadata
TitleUsporedba učestalosti višestrukih virusnih respiratornih infekcija u djece u ovisnosti o lokalizaciji infekcije i težini kliničke slike kod djece
Title (english)Comparison of the multiple viral respiratory infections incidence in dependence of the localization and clinical presentation of infections in children
AuthorInes Čižmek
MentorJasmina Vraneš (mentor)
Committee memberJasmina Vraneš (predsjednik povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
Committee memberDubravka Hranilović (član povjerenstva)
Committee memberMirna Ćurković Perica (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2010-11-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Infekcija dišnog sustava vodeći je uzrok hospitalizacije djece, posebice mlađe od godinu dana. U ovom istraživanju upotrebljena je brza i osjetljiva metoda (multipleks PCR test) za detekciju 12 respiratornih patogena uključujući virus influence A, virus influence B, virus parainfluence (PIV) tip 1, 2 i 3, respiratorni sincicijski virus (RSV) grupe A i B, adenovirus, ljudski rinovirus A i B, ljudski metapneumovirus (MPV), te koronaviruse OC43/HKU1 i 229E/NL63 u uzorcima iz respiratornog sustava... More 62 djeteta liječena u tromjesečnom razdoblju (veljača-svibanj) zbog infekcije dišnog sustava u Klinici za dječje bolesti u Zagrebu. Virusi su identificirani u 54 (87,1%) djece. Influenca A i influenca B virusi nisu detektirani, RSV je detektiran u 29 (46,8%), PIV u 25 (40,3%), rinovirus u 17 (27,4%), MPV u devet (14,5%), adenovirus u šest (9,7%) i koronavirusi u tri (4,8%) istraživana pacijenta. Koinfekcija s dva ili više virusa opažena je u 27 (50%) djece. Osamnaest pacijenata (60%) inficiranih RSV-om imalo je koinfekciju, dok je šest od devet pacijenata u kojih je dokazan MPV imalo koinfekciju (2/3). RSV je bio značajno udružen s infekcijama donjeg dišnog sustava (χ²=10,6; p<0,01). Prisutnost višestruke infekcije nije bila značajno povezana s težinom ili lokalizacijom infekcije (p>0,05). Multipleks PCR test je u dijagnostici najznačajnijih virusa koji izazivaju respiratorne infekcije osjetljiviji od konvencionalnih metoda, a rezultati su dostupni u klinički relevantnom vremenu. Daljnja istraživanja su potrebna da bi se bolje shvatilo značenje višestrukih infekcija. Less
Abstract (english)
Acute respiratory tract infection is a leading cause of hospitalization of children, particulary infants younger than one year. This study used a rapid and sensitive method (multiplex PCR assay) to detect 12 different respiratory pathogens including influenza A, influenza B, parainfluenza (PIV) types 1, 2 and 3, respiratory syncytial virus (RSV) groups A and B, adenovirus, human rhinovirus, human metapneumovirus (MPV) and human coronavirus OC43/HKU1 and 229E/NL63 from respiratory specimens of... More 62 children treated over 3-month period (February-May) for acute respiratory tract infections in the Clinic for children diseases in Zagreb. Viruses were identified in 54 (87.1%) of the children. Influenza A and influenza B viruses were not detected, RSV was detected in 29 (46.8%), PIV in 25 (40.3%), rhinovirus in 17 (27.4%), MPV in nine (14.5%), adenovirus in six (9.7%) and coronaviruses in three (4.8%) of the patients. Coinfections with two or more viruses were observed in 27 (50%) patients. Eighteen patients (60%) infected with RSV had a coinfection, while six out of nine patients tested positive for MPV had a coinfection (2/3). RSV was significantly associated with lower respiratory tract infections (χ²=10.6; p<0.01). Presence of a multiple infection was not significantly associated with severity or localization of the infection (p>0.05). Multiplex PCR assay is more sensitive for diagnosis of the main viruses that cause respiratory tract infections compared with conventional methods and obtains results in a clinically relevant time period. Further investigations are needed to broaden our understanding of the significance of multiple infections. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:008577
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-03 12:20:23
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