Exemplary education, as a modern teaching system that encourages active critical thinking in students, facilitates a comparative approach to teaching that studies relationships, similarities and differences between several subjects or phenomena with the aim of drawing certain conclusions. The aim of the thesis was to create a digital collection of three-dimensional models of the skulls of representatives of five different groups of vertebrate (pike from the class Actinopterygii, brown toad from the class Amphibia, colorful boa from the class Reptilia, domestic chicken from the class Aves and brown rat from the class Mammalia) and to analyze the possibility of its integration in primary and secondary schools for the subject of Biology. One skull of each selected representative was scanned with a CT device, after which the created images were processed using computer programs for 3D modeling. Each skull bone is named according to the official list of anatomical terms while homologous bones are marked with the same color in different species. Access to the 3D collection is free and available on the website of the Department of Anatomy, Histology and Embryology of the Faculty of Veterinary Medicine, University of Zagreb. After the analysis of the national curriculum for the subject of Biology and the annual implementation curricula proposed by the ministry, it is clear that the prepared material can be useful in achieving certain learning outcomes. Furthermore, it could also contribute to the realization of the results of teaching programs of individual courses in higher education.