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doctoral thesis
IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:144487
Pribić, Tea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Pribić, T. (2023). IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:144487

Pribić, Tea. "IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:144487

Pribić, Tea. "IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:144487

Pribić, T. (2023). 'IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:144487

Pribić T. IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:144487

T. Pribić, "IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:144487

Metadata
TitleIMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE
Title (croatian)GLIKOZILACIJA IMUNOGLOBULINA G U BOLESTI COVID-19
AuthorTea Pribić
MentorIrena Trbojević Akmačić (mentor)
Committee memberOlga Gornik Kljaić (predsjednik povjerenstva)
Committee memberDijana Škorić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-04-03, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become one of the major health problems in the world. SARS-CoV-2 infection leads to a disease caused by coronavirus (COVID-19), with a spectrum of symptoms ranging from asymptomatic to life-threatening pneumonia and death. A variation in the severity of disease symptomsis one of the central questions in COVID-19 pandemics. Immunoglobulin G (IgG), the most abundant glycoprotein in human blood plasma, is one of the key molecules in immune response. Glycosylation of IgG has been poorly studied in COVID-19, but previous studies on a small sample size have shown that there is an association between glycosylation of IgG and COVID-19 severity. As a part of this doctoral thesis study, the variability of IgG N-glycome in COVID-19 will be extensively studied for the first time, in relation to the disease severity and time period after diagnosis.
Abstract (croatian)
Pandemija koronavirusa 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) koji izaziva teški akutni respiratorni sindrom postala je jedan od glavnih zdravstvenih problema u svijetu. Infekcija SARS-CoV-2 dovodi do bolesti uzrokovane koronavirusom (COVID-19) sa spektrom simptoma koji se kreću od asimptomatske bolesti do po život opasne upale pluća i smrti. Uzroci razlika u jačini simptoma kod zaraženih jedno je od glavnih pitanja u pandemiji COVID-19. Imunoglobulin G (IgG), najzastupljeniji glikoprotein u ljudskoj krvnoj plazmi, jedna je od ključnih molekula u imunosnom odgovoru. Unatoč tome, glikozilacija IgG-a je do sada slabo proučavana u bolesnika s COVID-19, a dosadašnje studije na malom broju uzoraka su pokazale da postoji povezanost glikozilacije IgG-a i težine bolesti COVID-19. U sklopu ovog doktorskog istraživanja prvi put će biti detaljno analizirana varijabilnost IgG N-glikoma u COVID-19, ovisno o jačini simptoma te vremenu trajanja bolesti.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:217:144487
Promotion2023
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-04-03
Terms of useLicence In copyright icon
Created on2023-05-04 11:02:21