prikaz prve stranice dokumenta Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu
Embargo period 2025-05-31
master's thesis
Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:177772
Glazer, Lucija
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Glazer, L. (2023). Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:177772

Glazer, Lucija. "Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:177772

Glazer, Lucija. "Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:177772

Glazer, L. (2023). 'Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu', Master's thesis, University of Zagreb, Faculty of Science, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:177772

Glazer L. Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:217:177772

L. Glazer, "Termodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:177772

Metadata
TitleTermodinamičko i strukturno istraživanje kompleksiranja metilnih estera tetra i heksafenilalanina s anionima u acetonitrilu
Title (english)Thermodynamic and structural studies on the complexation of methyl esters of tetra and hexaphenylalanine with anions in acetonitrile
AuthorLucija Glazer
MentorGordan Horvat (mentor)
Committee memberGordan Horvat (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberTajana Begović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2023-05-31, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Ciklički peptidi predstavljaju posebno zanimljivu klasu supramolekulskih anionskih receptora zbog svoje raznolikosti i vrlo dobrih kompleksacijskih svojstava. Prvi korak sinteze cikličkih peptida je priprava njihovih linearnih analoga, a zatim se provodi reakcija ciklizacije. Najvažnija komponenta uspješne ciklizacije je konformacijska preorganizacija linearnog peptida u kojoj dolazi do približavanja N i C reaktivnih krajeva. Preorganizacija se može pospješiti korištenjem templatnih iona. U ovom radu istraženo je kompleksiranje metilnih estera linearnog tetra i heksafenilalanina s halogenidnim i oksoanionima u acetonitrilu. Konstante stabilnosti nastalih kompleksa određene su metodama 1H NMR spektroskopije, spektrofluorimetrije i spektroskopije cirkularnog dikroizma. Strukturne karakteristike anionskih kompleksa oba receptora istražene su simulacijama molekulske dinamike. Rezultati upućuju na to da su anioni koordinirani pomoću amidnih i amino protona peptida. Većina nastalih kompleksa je stehiometrije 1:1, osim u slučaju dihidrogenfosfata kod kojeg je uočena i stehiometrija 1:2 (receptor:anion)
Abstract (english)
Cyclic peptides represent a particularly interesting class of supramolecular anion receptors due to their diversity and good complexation properties. The first step in the synthesis of cyclic peptides is the preparation of their linear analogues after which the cyclization is carried out. The most important factor for a successful cyclization is the conformational reorganization of the linear peptide, in which the N and C reactive ends approach each other. Reorganization can be enhanced using templating ions. In this work, the complexation of methyl esters of linear tetra and hexaphenylalanine with halide and oxoanions in acetonitrile was investigated. The stability constants of corresponding complexes were determined by 1H NMR spectroscopy, spectrofluorimetry and circular dichroism spectroscopy. The structural characteristics of the anionic complexes of both receptors were investigated by molecular dynamics simulations as well. The results indicate that the anions are coordinated by the amide and amino protons of the peptide. Most of the resulting complexes are of 1:1 stoichiometry, except in the case of dihydrogen phosphate, where a 1:2 stoichiometry (receptor:anion) was also observed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:177772
ProjectNumber: IP-2019-04-9560
Title: Koordinacijske reakcije makrocikličkih liganada u otopini
Title: Coordination Reactions of Macrocyclic Ligands in Solution
Acronym: MacroSol
Leader: Vladislav Tomišić
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-05-31
Terms of useLicence In copyright icon
Created on2023-06-09 08:52:33