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doctoral thesis
Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:400256
Kalčec, Nikolina
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Kalčec, N. (2023). Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:400256

Kalčec, Nikolina. "Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:400256

Kalčec, Nikolina. "Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:400256

Kalčec, N. (2023). 'Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:400256

Kalčec N. Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:400256

N. Kalčec, "Design and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:400256

Metadata
TitleDesign and characterization of gold and selenium nanoparticles as potential delivery systems of levodopa and dopamine
Title (croatian)Dizajn i karakterizacija nanočestica zlata i selena kao potencijanih sustava za dostavu levodope i dopamina
AuthorNikolina Kalčec
MentorIvana Vinković Vrček (mentor)
MentorFrances Separovic https://orcid.org/0000-0002-6484-2763 (mentor)
Committee memberSnežana Miljanić (predsjednik povjerenstva)
Committee memberMaja Dutour Sikirić (član povjerenstva)
Committee memberMarko Močibob (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2023-05-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
The development of new approaches in the treatment of Parkinson's disease presents a challenge due to the presence of the blood-brain barrier, which hinders effective drug delivery to the brain. Due to their unique physicochemical properties, nanoparticles have the potential to improve conventional therapeutic approaches and enable targeted drug delivery across the blood-brain barrier. The main goal of this doctoral thesis was to synthesize and characterize differently functionalized gold and selenium nanoparticles and to examine their interaction with catechols (levodopa and dopamine) in order to design more effective and safer therapeutic systems for Parkinson's disease. The process of drug binding to the nano-surface was investigated using various spectroscopic, laser and microscopic methods, while the bloodbrain barrier permeability of prepared nano-systems was tested under in vitro settings. The obtained results have provided a better understanding of the processes that occur during the binding of catechol drugs to gold and selenium nanoparticles. This will potentially enable the development of a nano-formulation with targeted drug delivery to the brain with the aim of improving the therapy of Parkinson's disease.
Abstract (croatian)
Razvoj novih pristupa u liječenju Parkinsonove bolesti predstavlja izazov zbog prisutnosti krvno-moždane barijere koja otežava učinkovitu dostavu lijekova u mozak. Zahvaljujući jedinstvenim fizikalno-kemijskim svojstvima, nanočestice imaju potencijal poboljšati konvencionalne terapijske pristupe i omogućiti ciljanu isporuku lijekova preko krvnomoždane barijere. Glavni cilj ovog doktorskog rada bio je sintetizirati i karakterizirati različito funkcionalizirane nanočestice zlata i selena te ispitati njihovo međudjelovanje s kateholima (levodopa i dopamin) u svrhu dizajniranja učinkovitijih i sigurnijih terapijskih sustava za liječenje Parkinsonove bolesti. Proces vezanja lijekova na nano-površinu ispitivao se pomoću različitih spektroskopskih, laserskih i mikroskopskih metoda, a zatim su se provela istraživanja propusnosti krvno-moždane barijere za novopripravljene nanosustave u in vitro uvjetima. Dobiveni rezultati omogućili su bolje razumijevanje procesa koji se događaju prilikom vezanja lijekova kateholne strukture i novih nanočestica zlata i selena. Na taj način potiče se razvoj nano-formulacija s ciljanom isporukom lijekova u mozak s ciljem poboljšanja terapije za Parkinsonovu bolest.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:217:400256
Promotion2023
ProjectNumber: PZS-2019-02-4323
Title: Siguran pristup za razvoj nano-sustava za ciljanu isporuku lijekova u mozak
Title: Safe-by-Design Approach for Development of Nano-Enabled-Delivery Systems to Target the Brain
Acronym: SENDER
Leader: Ivana Vinković Vrček
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: PZS
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent141 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-06-12 10:25:00