prikaz prve stranice dokumenta VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE
  Download
PDF 432.73 KB
undergraduate thesis
VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:181976
Jendriš, Marija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jendriš, M. (2023). VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:181976

Jendriš, Marija. "VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:181976

Jendriš, Marija. "VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:181976

Jendriš, M. (2023). 'VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:181976

Jendriš M. VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:181976

M. Jendriš, "VAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:181976

Metadata
TitleVAŽNOST RAZVOJA TERAPIJE FAGIMA U ERI ANTIBIOTSKE REZISTENCIJE
Title (english)IMPORTANCE OF PHAGE THERAPY IN ANTIBIOTIC RESISTANCE ERA
AuthorMarija Jendriš
MentorDijana Škorić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Bakteriofagi su virusi koji inficiraju bakterije i moguće ih je koristiti u borbi protiv bakterija rezistentnih na antibiotike. Terapija fagima ne treba nužno zamijeniti antibiotike u liječenju već se može koristit zajedno s njima čime se postiže sinergistički efekt. Kako bi fage dostavili sigurno na mjesto infekcije koriste se različiti tipovi pripravaka – tekući, suhi (u obliku praška) i pripravci s inkapsuliranim fagima. Svi oblici pripravaka imaju svoje prednosti i nedostatke te se daljnja istraživanja trebaju usredotočiti na poboljšanje stabilnosti, učinkovitosti i sigurnosti isporuke. Zasada, inkapsulacija faga u liposome, hidrogel ili na površinu vlakana pokazuje obećavajuće rezultate . Omogućava fagima dolazak na mjesto infekcije, lakšu penetraciju u tkiva i štiti ih od razgradnje. Trebalo bi dodatno istražiti i razmotriti mogućnost razvoja sintetskih faga koji bi imali promjenjivu domenu za vezanje na receptore. Takve fage bi mogli koristiti u terapiji protiv širokog spektra bakterijskih infekcija.
Abstract (english)
Bacteriophages are viruses that infect bacteria. Bacteriophages can be used to treat diseases caused by antibiotic-resistant bacteria. That does not mean that phage therapy should replace antibiotics instead, it can be used with them which results in a synergetic effect. To ensure phages are safely delivered to the site of infection, various types of preparations are used – liquid, solid (in powder form) and preparations with encapsulated phages. Each form of preparation has its advantages and disadvantages and further research should focus on improving stability, effectiveness and delivery safety. Currently, the encapsulation of phages in liposomes, hydrogels and on the fiber surface shows the most promising results. These types of preparations allow phages to reach the site of infection, protects them from degradation and facilitates tissue penetration. Additional research and consideration should be given to the development of synthetic phages with variable receptor-binding domains. Such phages could be used in therapy against a broad spectrum of bacterial infections.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:181976
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-07-17
Terms of useLicence In copyright icon
Created on2023-07-24 09:20:58