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undergraduate thesis
Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:226313
Gregurić, Korina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Gregurić, K. (2023). Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:226313

Gregurić, Korina. "Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:226313

Gregurić, Korina. "Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:226313

Gregurić, K. (2023). 'Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 13 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:226313

Gregurić K. Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 May 13] Available at: https://urn.nsk.hr/urn:nbn:hr:217:226313

K. Gregurić, "Histon deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:226313

Metadata
TitleHiston deacetilaze i inhibitori histon deacetilaza u razvoju i terapiji tumora
Title (english)Histone deacetylases and inhibitors of histone deacetylase in tumor development and therapy
AuthorKorina Gregurić
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Acetilacija histona je epigenetička pottranslacijska modifikacija proteina pri kojoj ne dolazi do promjene u primarnoj strukturi molekule DNA. Sama acetilacija kontrolirana je dvama enzima suprotna djelovanja, acetilazom histona (engl. histone acetyltransferase, HAT) i deacetilazom histona (engl. histone deacetylase, DHAC). Deacetilaza histona funkcionira na način da reverzibilno uklanja acetilne skupine s proteina utječući tako na transkripciju onkogena i tumorsupresor gena. Prilikom tumorigeneze neregulirana deacetilacija utječe na brojne procese koji dodatno pomažu u razvoju tumorskih stanica npr. angiogeneza, stanična proliferacija, metastaziranje i brojne druge. Osim histonskih proteina deacetilaze mogu djelovati i na nehistonske proteine čime dodatno utječu na regulaciju translacije i kontrolne točke u staničnom ciklusu. Kako bi se riješio problem nekontroliranog rada deacetilaza, znanstvenici su razvili kemijske spojeve koji djeluju kao inhibitori histon deacetilaza. Njihovim hiperacetiliranjem proteina dolazi do ponovnog uspostavljanja acetilacijske homeostaze i normalnog staničnog rasta, sprječavajući tako razvitak tumora.
Abstract (english)
Histone acetylation is an epigenetic posttranslational protein modification that does not change the primary structure of the DNA molecule. Acetylation itself is controlled by two enzymes with opposite effects, histone acetylase (engl. histone acetyltransferase, HAT) and histone deacetylase (engl histone deacetylase, DHAC). Histone deacetylase functions by reversibly removing acetyl groups from proteins, thus affecting the transcription of proteins involved in tumor suppression processes. During tumorigenesis, unregulated deacetylation affects numerous processes that additionally help in the development of tumor cells, for example, angiogenesis, cell proliferation, metastasis and many others. In addition to histone proteins, deacetylases can also act on non-histone proteins, thereby additionally affecting translation regulation and control points in the cell cycle. In order to solve the problem of uncontrolled activity of deacetylases, scientist have developed chemical agents that act as histone deacetylase inhibitors. Their hyperacetylation of proteins leads to re-establishment of acetylation homeostasis and normal cell growth, thus preventing the development of tumors.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:226313
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-20 12:41:08