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undergraduate thesis
Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:369135
Barić, Helena Marta
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Barić, H. M. (2023). Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:369135

Barić, Helena Marta. "Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:369135

Barić, Helena Marta. "Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji." Undergraduate thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:369135

Barić, H. M. (2023). 'Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:369135

Barić HM. Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:369135

H. M. Barić, "Hipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:369135

Metadata
TitleHipertermija u liječenju malignih tumora: biološki mehanizmi, primjena i napredak u terapiji
Title (english)Hyperthermia in the treatment of malignant tumors: biological mechanisms, application and progress in therapy
AuthorHelena Marta Barić
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Hipertermija je terapeutski oblik u kojem se temperatura tkiva podiže iznad fiziološke na određeno vrijeme. Primjena blage hipertermije (40 – 43 °C) može izazvati subletalne uvjete u tumorima i često se koristi kao dodatak radio- i kemoterapiji. Kemoterapeutike dijelimo na one koji ne ovise o temperaturi, one koji uz hipertermiju imaju aditivni učinak i one koji imaju sinergistički učinak. Hipertermija onesposobljava mehanizme popravka DNA, čime pojačava učinkovitost ovih terapija. Nadalje, na povišenu temperaturu posebno su osjetljive radiootporne stanice u osiromašenom okruženju. Blaga hipertermija na imunosni sustav utječe poput vrućice te sudjeluje u novačenju limfocita u tumore, povećava osjetljivost tumorskih stanica i potiče povećanu ekspresiju proteina toplinskog šoka. Hipertermiji može biti izloženo cijelo tijelo ili samo dio, pa možemo govoriti o sustavnoj ili lokalnoj hipertermiji. Hipertermija se može postići vodenom kupelji, hladnim izvorom svjetlosti, primjenom laserske svjetlosti u bliskom infracrvenom području, fokusiranim ultrazvukom i uređajima za kapacitivnu hipertermiju. Iako su jasno vidljive prednosti korištenja hipertermije u liječenju malignih oboljenja, ova terapija nije još široko rasprostranjena poput radioi kemoterapije.
Abstract (english)
Hyperthermia is a therapeutic modality in which tissue temperature is elevated above the physiological range for a defined period of time. Mild hyperthermia (40 – 43 °C) can induce sublethal conditions in tumors and is often used as an adjunct to radiotherapy and chemotherapy. Chemotherapeutic agents can be categorized into those that are temperature-independent, those that have an additive effect with hyperthermia, and those that exhibit a synergistic effect. Hyperthermia impairs DNA repair mechanisms, thereby enhancing the effectiveness of these therapies. Furthermore, heat-sensitive radioresistant cells in a deprived environment are particularly vulnerable to elevated temperatures. Mild hyperthermia affects the immune system similarly to fever, recruiting lymphocytes to tumors, increasing the sensitivity of tumor cells, and promoting increased expression of heat shock proteins. Hyperthermia can be applied to the whole body or on a specific part, leading to systemic or local hyperthermia. Hyperthermia can be achieved using a water bath, cold light sources, near-infrared laser, focused ultrasound, and capacitive hyperthermia devices. Despite the clear advantages of using hyperthermia in the treatment of malignant conditions, this therapy is not yet as widely adopted as radiotherapy and chemotherapy
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:369135
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-26 12:47:55