prikaz prve stranice dokumenta Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)
Embargo period 2025-09-21
master's thesis
Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:907229
Mandić, Aleksandar
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Mandić, A. (2023). Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA) (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:907229

Mandić, Aleksandar. "Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:907229

Mandić, Aleksandar. "Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:907229

Mandić, A. (2023). 'Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)', Master's thesis, University of Zagreb, Faculty of Science, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:907229

Mandić A. Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:217:907229

A. Mandić, "Razvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:907229

Metadata
TitleRazvoj sintetskog puta za pripravu konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA)
Title (english)Synthetic route development for the preparation of the conjugate of D-glucose and diethylenetriaminepentaacetic acid (DTPA)
AuthorAleksandar Mandić
MentorĐani Škalamera (mentor)
MentorMarina Šekutor (mentor)
Committee memberĐani Škalamera (predsjednik povjerenstva)
Committee memberBiserka Prugovečki (član povjerenstva)
Committee memberAleksandra Maršavelski (član povjerenstva)
Committee memberVesna Petrović Peroković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2023-09-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U sklopu ovog diplomskog rada pripravljen je „late-stage” međuprodukt koji se sastoji od benzilirane D-glukoze i trietilen-glikol-ditosilata (10) u svrhu priprave konjugata D-glukoze i dietilentriaminpentaoctene kiseline (DTPA) (1). Konjugat 1 teranostički je agens koji se može koristiti u ciljanoj dostavi radiofarmaceutika u stanice raka, a sve u svrhu radioterapije i/ili dijagnostike. Ukupna struktura konjugata 1 sastavljena je od tri jedinice: D-glukoze, trietilenglikola i DTPA. U ovom radu ispitana je uspješnost nekoliko različitih sintetskih pristupa u pripravi spoja 1. Rad uključuje sintezu, pročišćavanje, izolaciju i karakterizaciju dobivenih međuprodukata. Sam cilj ovog rada je pronalazak efikasne sintetske rute do spoja 1 sa što manje koraka, a sa što većim prinosom, polazeći iz komercijalno dostupnih spojeva. Dobiveni spojevi okarakterizirani su spektroskopskim metodama (IR, 1H i 13C NMR).
Abstract (english)
In this diploma thesis „late-stage” intermediate for the preparation of the conjugate of D-glucose and diethylenetriaminepentaacetic acid (DTPA) (1) was synthesized, consisting of benzylated D-glucose and triethylene glycol ditosylate (10). Conjugate 1 is a theranostic agent, whose structure can be used for the selective delivery of radiopharmaceutics into cancer cells with the aim of a radiotherapy treatment and/or diagnostics. The full structure of 1 is comprised of: D-glucose, triethylene glycol and DTPA. In this work, the effectiveness of several different synthetic approaches in the preparation of compound 1 was examined. The thesis includes the synthesis, purification, isolation and characterization of prepared intermediates in the synthetic route. The aim of this work is to find an efficient synthetic route towards compound 1 with as few steps as possible, and with as high a yield as possible, starting from commercially available compounds. Obtained compounds were characterized with spectroscopic methods (IR, 1H and 13C NMR).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:907229
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-09-21
Terms of useLicence In copyright icon
Created on2023-10-13 13:03:28